IBMX
IUPAC name	1-methyl-3-(2-methylpropyl)-7H-purine-2,6-dione
Other names	3-Isobutyl-1-methylxanthine
Identifiers
CAS number	28822-58-4 Y
PubChem	3758
SMILES	CC(C)CN1C2=C(C(=O)N(C1=O)C)NC=N2
Properties
Molecular formula	C10H14N4O2
Molar mass	222.3 g/mol
Appearance	White solid
Melting point	199-201 °C
Solubility	Soluble in ethanol, DMSO, and methanol
Y (what is this?)  (verify) Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

IBMX, 3-isobutyl-1-methylxanthine, like other methylated xanthine derivatives, is both a

1. competitive nonselective phosphodiesterase inhibitor ^[1] which raises intracellular cAMP, activates PKA, inhibits TNF-alpha ^{[2] [3]} and leukotriene ^[4] synthesis, and reduces inflammation and innate immunity ^[4] and
2. nonselective adenosine receptor antagonist ^[5].

As a phosphodiesterase inhibitor, IBMX has IC₅₀ = 2-50 μM ^[6] and does not inhibit PDE8 or PDE9 ^[7].

[edit] References

1. ^ Essayan DM. (2001). "Cyclic nucleotide phosphodiesterases.". J Allergy Clin Immunol. 108 (5): 671-80. doi:10.1067/mai.2001.119555. PMID 11692087. 
2. ^ Deree J, Martins JO, Melbostad H, Loomis WH, Coimbra R. (2008). "Insights into the regulation of TNF-alpha production in human mononuclear cells: the effects of non-specific phosphodiesterase inhibition.". Clinics (Sao Paulo). 63 (3): 321-8. doi:10.1590/S1807-59322008000300006. PMID 18568240. 
3. ^ Marques LJ, Zheng L, Poulakis N, Guzman J, Costabel U (February 1999). "Pentoxifylline inhibits TNF-alpha production from human alveolar macrophages". Am. J. Respir. Crit. Care Med. 159 (2): 508–11. PMID 9927365. http://ajrccm.atsjournals.org/cgi/pmidlookup?view=long&pmid=9927365. 
4. ^ ^{a b} Peters-Golden M, Canetti C, Mancuso P, Coffey MJ. (2005). "Leukotrienes: underappreciated mediators of innate immune responses.". J Immunol. 174 (2): 589-94. PMID 15634873. http://www.jimmunol.org/cgi/content/full/174/2/589. 
5. ^ Daly JW, Jacobson KA, Ukena D. (1987). "Adenosine receptors: development of selective agonists and antagonists.". Prog Clin Biol Res. 230 (1):  :41-63. PMID 3588607. 
6. ^ J.A.Beavo et al. Mol. Pharmacol. 1970 6 597
7. ^ Soderling and Beavo Current Opinion in Cell Biol. 2000 12 174

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