An irreversible antagonist is a type of antagonist that binds permanently to a receptor, either by forming a covalent bond to the active site, or alternatively just by binding so tightly that the rate of dissociation is effectively zero at relevant time scales.^[1] This permanently deactivates the receptor and is usually followed by rapid internalisation and recycling of the non-functional receptor protein.

[edit] Examples

• Naloxazone

[edit] See also

• Irreversible agonist
• Irreversible enzyme inhibitor

[edit] References

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