3-Iodothyronamine Information & 3-Iodothyronamine Links at HealthHaven.com

3-Iodothyronamine
IUPAC name	4-[4-(2-Amino-ethyl)-2-iodo-phenoxy]-phenol
Other names	T1AM
Identifiers
CAS number	712349-95-6
SMILES	OC1=CC=C(OC2=C(I)C=C(CCN)C=C2)C=C1
Properties
Molecular formula	C14H14INO2
Molar mass	355.17 g/mol
	Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
	Infobox references

3-iodothyronamine (T₁AM) is an endogenous thyronamine. T₁AM is a high-affinity ligand for the trace amine-associated receptor TAAR1 (TAR1, TA1), a G protein-coupled receptor.^[1]^[2] When injected into rodents, T₁AM causes a rapid drop in body temperature and alterations in blood pressure and heart rate.^[3]

T₁AM may be part of a signaling pathway to modulate cardiac function as the compound can induce negative inotropic effects and decrease cardiac output.^[4]

[edit] See also

Trace amine

[edit] External links

MeSH 3-iodothyronamine

[edit] References

^ Scanlan T, Suchland K, Hart M, Chiellini G, Huang Y, Kruzich P, Frascarelli S, Crossley D, Bunzow J, Ronca-Testoni S, Lin E, Hatton D, Zucchi R, Grandy D (2004). "3-Iodothyronamine is an endogenous and rapid-acting derivative of thyroid hormone". Nat. Med. 10 (6): 638–42. doi:10.1038/nm1051. PMID 15146179.
^ Hart M, Suchland K, Miyakawa M, Bunzow J, Grandy D, Scanlan T (2006). "Trace amine-associated receptor agonists: synthesis and evaluation of thyronamines and related analogues". J. Med. Chem. 49 (3): 1101–12. doi:10.1021/jm0505718. PMID 16451074.
^ "New compound may act to keep thyroid activity in check". http://www.eurekalert.org/pub_releases/2004-05/ohs-ncm051404.php. Retrieved 2008-05-30.
^ Chiellini G, Frascarelli S, Ghelardoni S, Carnicelli V, Tobias SC, Debarber A, Brogioni S, Ronca-Testoni S, Cerbai E, Grandy DK, Scanlan TS, Zucchi R. (2007). Cardiac effects of 3-iodothyronamine: a new aminergic system modulating cardiac function. PMID 17284482.

[0] Scanlan T, Suchland K, Hart M, Chiellini G, Huang Y, Kruzich P, Frascarelli S, Crossley D, Bunzow J, Ronca-Testoni S, Lin E, Hatton D, Zucchi R, Grandy D (2004). "3-Iodothyronamine is an endogenous and rapid-acting derivative of thyroid hormone". Nat. Med. 10 (6): 638–42. doi:10.1038/nm1051. PMID 15146179.

[1] Hart M, Suchland K, Miyakawa M, Bunzow J, Grandy D, Scanlan T (2006). "Trace amine-associated receptor agonists: synthesis and evaluation of thyronamines and related analogues". J. Med. Chem. 49 (3): 1101–12. doi:10.1021/jm0505718. PMID 16451074.

[2] "New compound may act to keep thyroid activity in check". http://www.eurekalert.org/pub_releases/2004-05/ohs-ncm051404.php. Retrieved 2008-05-30.

[3] Chiellini G, Frascarelli S, Ghelardoni S, Carnicelli V, Tobias SC, Debarber A, Brogioni S, Ronca-Testoni S, Cerbai E, Grandy DK, Scanlan TS, Zucchi R. (2007). Cardiac effects of 3-iodothyronamine: a new aminergic system modulating cardiac function. PMID 17284482.

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