| County | Location | Exit | Destinations | Notes |
Dillon County, South Carolina-Robeson County, North Carolina Border Interstate 95 leaves South Carolina |
| Robeson | Rowland | 1 |  US 301 / US 501 – Rowland, Laurinburg Hamer, SC | Signed as exits 1A & 1B southbound; serves South of the Border |
| 2 |  NC 130 to NC 904 – Rowland, Fairmont | |
| Thompson | 7 | East Raynham Road - McDonald, Raynham | |
| 10 | US 301 south – Fairmont | South end of US 301 overlap |
| Lumberton | 13 |  I-74 / US 74 – Laurinburg, Rockingham, Whiteville, Wilmington | Signed as exits 13A (east) and 13B (west) |
| 17 |  NC 72 / NC 711 – Lumberton, Pembroke | |
| Bridge across the Lumber River |
| 19 | Carthage Road | |
| 20 |  NC 211 to NC 41 – Lumberton, Red Springs | |
| 22 | US 301 north – Lumberton | North end of US 301 overlap |
| 25 | US 301 | |
| Cumberland | St. Pauls | 31 | NC 20 – St. Pauls, Raeford | |
| 33 |  US 301 to NC 71 – Parkton, St. Pauls | |
| 40 |  I-95 Bus. north / US 301 – Fayetteville, Fort Bragg, Pope AFB | Northbound exit and southbound entrance |
| 41 | NC 59 – Hope Mills, Fayetteville, Parkton, Cypress Lakes | |
| 44 | Snow Hill Road - Fayetteville Regional Airport | |
| 46 | NC 87 – Elizabethtown, Fayetteville | Signed as exits 46A (south) and 46B (north) |
| Fayetteville | 49 |  NC 53 / NC 210 – Fayetteville | |
| Vander | 52 | NC 24 – Fayetteville, Clinton, Methodist University | Signed as exits 52A (east) and 52B (west) |
| 55 | Murphy Road | |
| 56 |  I-95 Bus. south / US 301 – Fayetteville, Fort Bragg, Pope AFB | Southbound exit and northbound entrance |
| 58 |       US 13 / Future I-295 to US 401 - Newton Grove | |
| 61 | Wade-Steadman Road - Wade | |
| 65 | NC 82 – Godwin, Falcon | |
| Harnett | | 70 | Bud Hawkins & Robbie Ann Road | |
| 71 | Long Branch Road | |
| Dunn | 72 | Pope Road | |
| 73 |  US 421 / NC 55 – Dunn, Clinton, Newton Grove | |
| Averasboro | 75 | Jonesboro Road | |
| 77 | Hodges Chapel Road | |
| Johnston | Benson | 79 |   NC 50 / NC 242 to NC 27 – Benson, Newton Grove, Raleigh | |
| 81 | I-40 – Raleigh, Durham, Wilmington, Clinton | Signed as exits 81A (west) and 81B (east) southbound |
| Ingrams | 87 | (Keen Road) Four Oaks | Originally also served Hockaday Road[1] |
| 90 |  US 701 south / NC 96 – Newton Grove | |
| Smithfield | 93 | Brogden Road - Smithfield | |
| 95 |  US 70 Bus. – Smithfield, Goldsboro | |
| Selma | 97 | US 70 – Selma, Pine Level, Goldsboro | |
| Pine Level | 98 | Pine Level-Selma Road - Selma | |
| 101 | Pittman Road | |
| Micro | 102 | East Main Street - Micro | |
| Lower Mill | 105 | Bagley Road | |
| Beulah | 106 | Truck Stop Road | |
| 107 | US 301 – Kenly, Wilson | |
| Wilson | Old Fields | 116 | NC 42 – Rock Ridge, Wilson, Clayton | |
| 119 |   I-795 / US 117 / US 264 – Zebulon, Wilson, Greenville, Goldsboro | Signed as exits 119A (east/south) and 119B (west)/I-795 Is Not Signed From I-95 |
| Wilson | 121 |    US 264 Alt. – Wilson, Sims, Greenville | |
| Nash | Jackson | 127 | NC 58 – Nashville, Wilson | |
| Coopers | 132 | NC 97 – Stanhope, Zebulon, Rocky Mount | Ramp is on West Mount Drive (often erroneously called West Mountain Road) |
| Rocky Mount | 134 | Sunset Avenue | In planning stages with construction schedule to begin no later than 2012.[2] |
| 138 | US 64 – Nashville, Zebulon, Rocky Mount, Tarboro | Signed as exits 138A (east) 138B (west) |
| Dortches | 141 | NC 43 – Red Oak, Dortches, Rocky Mount | |
| South Whitakers | 145 |   NC 4 / NC 48 to US 301 – Gold Rock, Battleboro, Rocky Mount | |
| North Whitakers | 150 | NC 33 – Whitakers, Littleton, Gold Rock | |
| Halifax | Enfield | 154 | NC 481 – Enfield, Glenview | |
| 160 | NC 561 – Brinkleyville, Halifax | |
| 168 | NC 903 – Halifax, Littleton | |
| South Weldon | 171 | NC 125 – Roanoke Rapids, Halifax | |
| Roanoke Rapids | 173 | US 158 – Roanoke Rapids, Weldon, Murfreesboro | |
| Bridge across the Roanoke River (Lake Gaston) |
| Northampton |
| Gaston | 176 | NC 46 – Gaston, Garysburg | |
| Pleasant Hill | 180 | NC 48 – Gaston, Pleasant Hill | |
Northampton County, North Carolina-Greensville County, Virginia Border Interstate 95 continues north into Virginia |