interferon (alpha, beta and omega) receptor 1
Identifiers
Symbol	IFNAR1
Alt. symbols	IFNAR
Entrez	3454
HUGO	5432
OMIM	107450
RefSeq	NM_000629
UniProt	P17181
Other data
Locus	Chr. 21 q22.1

interferon (alpha, beta and omega) receptor 2
NMR structure of the interferon-binding ectodomain of the human interferon receptor.[1]
Identifiers
Symbol	IFNAR2
Alt. symbols	IFNABR
Entrez	3455
HUGO	5433
OMIM	602376
RefSeq	NM_207585
UniProt	P48551
Other data
Locus	Chr. 21 q22.1

The interferon-α/β receptor (IFNAR) is a receptor which binds type I interferons including interferon-α and -β. It is a heteromeric receptor composed of one chain with two subunits referred to as IFNAR1 and IFNAR2.^[2] It is a cell surface receptor. Binding of cytokine follows a JAK-STAT signaling pathway. Interferon stimulation results in a immunologic response that is especially associated with viruses.

Contents 1 Structure 2 SCOP Classification 3 References 4 External links

[edit] Structure

The structure was obtained using NMR. Originally 35 conformers were calculated. This was narrowed to 22 with low energy being the criteria. It was the first helical cytokine receptor's structure to be determined in solution. The molecule has one polymer The structure reveals the nature of binding. A model of the IFNAR2 reveals a predominantly hydrophobic patch on the receptor that interacts with a matching hydrophobic surface on IFN-alpha. An adjacent motif of charged side chains then guides the proteins into a tight complex. The binding interface may account for crossreactivity and ligand specificity of the receptor. The source for experiments was human but was expressed in Escherichia coli.

[edit] SCOP Classification

IFNAR is clustered into the group beta proteins based on its secondary structural content. IFNAR's folds show a clear evolutionary relationship to the Immunoglobulin beta-sandwich. It is grouped into the superfamily and family Fibronectin type III based on structural and functional similarities that show probable common evolution. The domain, or evolutionary unit observed in nature, is the Interferon-alpha/beta receptor beta chain. Species was human.

[edit] References

[edit] External links

• MeSH Receptor,+Interferon+alpha-beta

This biochemistry article is a stub. You can help Wikipedia by expanding it. v • d • e

v • d • e Transmembrane receptors: immune receptors Cytokine receptor Type I Interleukins (2, 3, 4, 5, 6, 7, 9, 11, 12, 13, 15, 21, 23, 27) CSF receptors (EPO, GM-CSF, G-CSF) GH · prolactin · Oncostatin M · Leukemia inhibitory factor common subunits (Common gamma chain, common beta chain, gp130) Type II Interleukins (10, 20, 22, 28) · interferon (-α/β, -γ) Ig superfamily CSF1 · C-kit · IL-1 · IL-18 TNF CD27 · CD30 · CD40 · CD120 · Lymphotoxin β Chemokines IL-8 (α, β), CCR1,CXCR4 Other IL-17 · TGF-beta (1, 2) · Thrombopoietin Other endogenous Fc receptor Epsilon (ε) FcεRI · FcεRII Gamma (γ) FcγRI · FcγRII · FcγRIII · Neonatal Alpha (α)/mu (μ) FcαRI · Fcα/μR Lymphocyte homing receptor CD44 · L-selectin · integrin (VLA-4, LFA-1) Other Complement · Immunophilins (Cyclophilin) · Integrin · Killer-cell immunoglobulin-like · Scavenger Exogenous Pattern recognition/Toll-like TLR 1 · TLR 2 · TLR 3 · TLR 4 · TLR 5 · TLR 6 · TLR 7 · TLR 8 · TLR 9 · TLR 10 Antigen receptor B-cell · T cell Other Formyl peptide