The Institute for OneWorld Health is a 501(c)(3) nonprofit pharmaceutical company founded in 2000 to develop safe, effective, and affordable new medicines for people with infectious diseases in the developing countries.

Contents 1 Drug development efforts 2 Executives 3 Major supporters 4 References 5 External links

[edit] Drug development efforts

Currently, two drugs are under development a drug to treat Chagas disease in Latin America and a drug to cure visceral leishmaniasis in India. Paromomycin, the drug being developed to treat visceral leishmaniasis, was granted orphan drug status in 2005 by both the FDA and EMEA.^[1] Prior to this approval, Phase 3 clinical trials for this indication were conducted in India in 2003—2004. The overall conclusion was that efficacy and side effects were similar to the comparison agent in the trials, amphotericin B, results which in August 2006 led to approval for treatment of visceral leishmaniasis by the Indian government.^[2]

[edit] Executives

• Dr. Victoria Hale Ph.D., CEO and Chairman of the Board of Directors.
• Dr. Ahvie Herskowitz M.D., COO and Chief Medical Officer.

[edit] Major supporters

• Bill & Melinda Gates Foundation^[3][4] (the Institute received 96% of its funding from the Foundation as of 2006)^[5]
• Amgen, Chiron Corporation, Gap, Lehman Brothers, Pfizer, Vital Spark Foundation, Skoll Foundation^[5]

[edit] References

1. ^ Radia, Hina (23 May 2005). "US FDA and EMEA grant “Orphan Drug” designation for paromomycin injection to treat visceral leishmaniasis". Biospace.com. Archived from the original on 2005-05-24. http://www.nelm.nhs.uk/Record%20Viewing/viewRecord.aspx?id=550188. Retrieved 2007-07-30.  (abstract preserved by National Health Service)
2. ^ Sundar, Shyam; T.K. Jha, Chandreshwar P. Thakur, Prabhat K. Sinha and Sujit K. Bhattacharya (21 June 2007). "Injectable Paromomycin for Visceral Leishmaniasis in India". New England Journal of Medicine 356 (25): 2571–2581. doi:10.1056/NEJMoa066536. PMID 17582067. http://content.nejm.org/cgi/content/full/356/25/2571. Retrieved 2007-07-30. 
3. ^ Bill & Melinda Gates Foundation (13 July 2004). "Institute for OneWorld Health Receives Gates Foundation Grant To Fund Development of Malaria Vaccine". Press release. http://www.gatesfoundation.org/GlobalHealth/Pri_Diseases/Malaria/Announcements/Announce-040713.htm. Retrieved 2007-07-30. 
4. ^ Bill & Melinda Gates Foundation (14 April 2005). "Institute for OneWorld Health Receives Grant To Lay Foundation for Next Steps in Control of Deadly Infectious Disease". Press release. http://www.gatesfoundation.org/GlobalHealth/Pri_Diseases/OtherInfectiousDiseases/Announcements/Announce-050414.htm. Retrieved 2007-07-30. 
5. ^ ^{a b} Shears, Angela Rickabaugh (25 September 2006). "Curing the Third World". Philanthropy Magazine (Philanthropy Roundtable). http://www.philanthropyroundtable.org/article.asp?article=1420&paper=1&cat=139. Retrieved 2007-07-31. 

[edit] External links

• The Institute for OneWorld Health official website

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