IRAK2 Information & IRAK2 Links at HealthHaven.com

Interleukin-1 receptor-associated kinase 2
Identifiers
Symbols	IRAK2; IRAK-2; MGC150550
External IDs	OMIM: 603304 MGI: 2429603 HomoloGene: 1207
Gene ontology
Molecular function	• protein kinase activity; • NF-kappaB-inducing kinase activity; • ATP binding; • identical protein binding;
Cellular component	• cell surface;
Biological process	• protein amino acid phosphorylation; • inflammatory response; • signal transduction; • I-kappaB kinase/NF-kappaB cascade; • lipopolysaccharide-mediated signaling pathway; • negative regulation of transcription factor activity; • activation of NF-kappaB transcription factor;
RNA expression pattern
	More reference expression data
Orthologs
NP_001561 (protein)	XP_979663 (protein)

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Interleukin-1 receptor-associated kinase-like 2 is an enzyme that in humans is encoded by the IRAK2 gene.^[1]^[2]

IRAK2 encodes the interleukin-1 receptor-associated kinase 2, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. IRAK2 is reported to participate in the IL1-induced upregulation of NF-kappaB.^[2]

[edit] Interactions

IRAK2 has been shown to interact with TRAF6^[3]^[1] and Myd88.^[3]^[4]^[1]

[edit] References

^ ^a ^b ^c Muzio M, Ni J, Feng P, Dixit VM (Dec 1997). "IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling". Science 278 (5343): 1612-5. PMID 9374458.
^ ^a ^b "Entrez Gene: IRAK2 interleukin-1 receptor-associated kinase 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3656.
^ ^a ^b Wesche, H; Gao X, Li X, Kirschning C J, Stark G R, Cao Z (Jul. 1999). "IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family". J. Biol. Chem. (UNITED STATES) 274 (27): 19403-10. ISSN 0021-9258. PMID 10383454.
^ Fitzgerald, K A; Palsson-McDermott E M, Bowie A G, Jefferies C A, Mansell A S, Brady G, Brint E, Dunne A, Gray P, Harte M T, McMurray D, Smith D E, Sims J E, Bird T A, O'Neill L A (Sep. 2001). "Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction". Nature (England) 413 (6851): 78-83. doi:10.1038/35092578. ISSN 0028-0836. PMID 11544529.

[edit] Further reading

Auron PE (1999). "The interleukin 1 receptor: ligand interactions and signal transduction.". Cytokine Growth Factor Rev. 9 (3-4): 221–37. doi:10.1016/S1359-6101(98)00018-5. PMID 9918122.
Maschera B, Ray K, Burns K, Volpe F (1999). "Overexpression of an enzymically inactive interleukin-1-receptor-associated kinase activates nuclear factor-kappaB.". Biochem. J. 339 ( Pt 2): 227–31. doi:10.1042/0264-6021:3390227. PMID 10191251.
Wesche H, Gao X, Li X, et al. (1999). "IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family.". J. Biol. Chem. 274 (27): 19403–10. doi:10.1074/jbc.274.27.19403. PMID 10383454.
Fitzgerald KA, Palsson-McDermott EM, Bowie AG, et al. (2001). "Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction.". Nature 413 (6851): 78–83. doi:10.1038/35092578. PMID 11544529.
McDermott EP, O'Neill LA (2002). "Ras participates in the activation of p38 MAPK by interleukin-1 by associating with IRAK, IRAK2, TRAF6, and TAK-1.". J. Biol. Chem. 277 (10): 7808–15. doi:10.1074/jbc.M108133200. PMID 11744690.
Shin BK, Wang H, Yim AM, et al. (2003). "Global profiling of the cell surface proteome of cancer cells uncovers an abundance of proteins with chaperone function.". J. Biol. Chem. 278 (9): 7607–16. doi:10.1074/jbc.M210455200. PMID 12493773.
Bin LH, Xu LG, Shu HB (2003). "TIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing adapter protein involved in TIR signaling.". J. Biol. Chem. 278 (27): 24526–32. doi:10.1074/jbc.M303451200. PMID 12721283.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Kuzmin I, Geil L, Gibson L, et al. (2005). "Transcriptional regulator CTCF controls human interleukin 1 receptor-associated kinase 2 promoter.". J. Mol. Biol. 346 (2): 411–22. doi:10.1016/j.jmb.2004.11.066. PMID 15670593.
Keating SE, Maloney GM, Moran EM, Bowie AG (2008). "IRAK-2 participates in multiple toll-like receptor signaling pathways to NFkappaB via activation of TRAF6 ubiquitination.". J. Biol. Chem. 282 (46): 33435–43. doi:10.1074/jbc.M705266200. PMID 17878161.

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[pmid9374458-0] Muzio M, Ni J, Feng P, Dixit VM (Dec 1997). "IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling". Science 278 (5343): 1612-5. PMID 9374458.

[entrez-1] "Entrez Gene: IRAK2 interleukin-1 receptor-associated kinase 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3656.

[pmid10383454-2] Wesche, H; Gao X, Li X, Kirschning C J, Stark G R, Cao Z (Jul. 1999). "IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family". J. Biol. Chem. (UNITED STATES) 274 (27): 19403-10. ISSN 0021-9258. PMID 10383454.

[pmid11544529-3] Fitzgerald, K A; Palsson-McDermott E M, Bowie A G, Jefferies C A, Mansell A S, Brady G, Brint E, Dunne A, Gray P, Harte M T, McMurray D, Smith D E, Sims J E, Bird T A, O'Neill L A (Sep. 2001). "Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction". Nature (England) 413 (6851): 78-83. doi:10.1038/35092578. ISSN 0028-0836. PMID 11544529.

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