Inositol trisphosphate receptor (IP3R) is a membrane glycoprotein complex acting as Ca²⁺ channel activated by inositol trisphosphate (IP3). The IP3 receptor was first purified from rat cerebellum^[1].

[edit] Distribution

It has a broad tissue distribution but is especially abundant in the cerebellum. Most of the IP3Rs are found in the cell integrated into the endoplasmic reticulum.

[edit] Structure

The IP3R complex is formed of four 313 kDa subunits. In amphibians, fish and mammals there are 3 paralogs and these can form homo- or hetero-oligomers. IP3R-1 is the most widely expressed of these three and is found in all tissue types and all developmental stages of life. It is additionally the means for further IP3 receptor diversity in that it has as many as four splice sites with as many as 9 different optional exons or exon variants. Combinations of these can be introduced into a given transcript in order to modulate its pharmacological activity.

[edit] See also

• inositol
• inositol phosphate
  • inositol monophosphate
  • inositol trisphosphate
  • inositol pentakisphosphate
  • inositol hexaphosphate
• MRVI1 associated through complex formation.

[edit] References

[edit] External links

• MeSH Inositol+Trisphosphate+Receptor

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