INCENP Information & INCENP Links at HealthHaven.com

Inner centromere protein antigens 135/155kDa
Identifiers
Symbols	INCENP; FLJ31633; MGC111393
External IDs	OMIM: 604411 MGI: 1313288 HomoloGene: 9624 GeneCards: INCENP Gene
Gene ontology
Molecular function	• protein binding;
Cellular component	• central element; • nucleus; • centric heterochromatin; • spindle; • microtubule; • midbody; • protein complex;
Biological process	• cytokinesis; • cell cycle; • chromosome segregation; • mitosis;
RNA expression pattern
	More reference expression data
Orthologs

edit

Inner centromere protein is a protein that in humans is encoded by the INCENP gene.^[1]^[2]^[3]

In mammalian cells, 2 broad groups of centromere-interacting proteins have been described: constitutively binding centromere proteins and 'passenger,' or transiently interacting, proteins (reviewed by Choo, 1997). The constitutive proteins include CENPA (centromere protein A; MIM 117139), CENPB (MIM 117140), CENPC1 (MIM 117141), and CENPD (MIM 117142). The term 'passenger proteins' encompasses a broad collection of proteins that localize to the centromere during specific stages of the cell cycle (Earnshaw and Mackay, 1994). These include CENPE (MIM 117143); MCAK (MIM 604538); KID (MIM 603213); cytoplasmic dynein (e.g., MIM 600112); CliPs (e.g., MIM 179838); and CENPF/mitosin (MIM 600236). The inner centromere proteins (INCENPs) (Earnshaw and Cooke, 1991), the initial members of the passenger protein group, display a broad localization along chromosomes in the early stages of mitosis but gradually become concentrated at centromeres as the cell cycle progresses into mid-metaphase. During telophase, the proteins are located within the midbody in the intercellular bridge, where they are discarded after cytokinesis (Cutts et al., 1999).[supplied by OMIM]^[3]

[edit] Interactions

INCENP has been shown to interact with H2AFZ,^[4] Survivin^[5] and CDCA8.^[6]

[edit] References

^ Earnshaw WC, Cooke CA (Sep 1991). "Analysis of the distribution of the INCENPs throughout mitosis reveals the existence of a pathway of structural changes in the chromosomes during metaphase and early events in cleavage furrow formation". J Cell Sci 98 ( Pt 4): 443–61. PMID 1860899.
^ Adams RR, Eckley DM, Vagnarelli P, Wheatley SP, Gerloff DL, Mackay AM, Svingen PA, Kaufmann SH, Earnshaw WC (Jul 2001). "Human INCENP colocalizes with the Aurora-B/AIRK2 kinase on chromosomes and is overexpressed in tumour cells". Chromosoma 110 (2): 65–74. PMID 11453556.
^ ^a ^b "Entrez Gene: INCENP inner centromere protein antigens 135/155kDa". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3619.
^ Rangasamy, Danny; Berven Leise, Ridgway Patricia, Tremethick David John (Apr. 2003). "Pericentric heterochromatin becomes enriched with H2A.Z during early mammalian development". EMBO J. (England) 22 (7): 1599–607. doi:10.1093/emboj/cdg160. ISSN 0261-4189. PMID 12660166.
^ Wheatley, S P; Carvalho A, Vagnarelli P, Earnshaw W C (Jun. 2001). "INCENP is required for proper targeting of Survivin to the centromeres and the anaphase spindle during mitosis". Curr. Biol. (England) 11 (11): 886–90. ISSN 0960-9822. PMID 11516652.
^ Gassmann, Reto; Carvalho Ana, Henzing Alexander J, Ruchaud Sandrine, Hudson Damien F, Honda Reiko, Nigg Erich A, Gerloff Dietlind L, Earnshaw William C (Jul. 2004). "Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle". J. Cell Biol. (United States) 166 (2): 179–91. doi:10.1083/jcb.200404001. ISSN 0021-9525. PMID 15249581.

[edit] Further reading

Ainsztein AM, Kandels-Lewis SE, Mackay AM, Earnshaw WC (1999). "INCENP centromere and spindle targeting: identification of essential conserved motifs and involvement of heterochromatin protein HP1.". J. Cell Biol. 143 (7): 1763–74. doi:10.1083/jcb.143.7.1763. PMID 9864353.
Martineau-Thuillier S, Andreassen PR, Margolis RL (1999). "Colocalization of TD-60 and INCENP throughout G2 and mitosis: evidence for their possible interaction in signalling cytokinesis.". Chromosoma 107 (6-7): 461–70. doi:10.1007/s004120050330. PMID 9914378.
Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. doi:10.1073/pnas.97.7.3491. PMID 10737800.
Wheatley SP, Kandels-Lewis SE, Adams RR, et al. (2001). "INCENP binds directly to tubulin and requires dynamic microtubules to target to the cleavage furrow.". Exp. Cell Res. 262 (2): 122–7. doi:10.1006/excr.2000.5088. PMID 11139336.
Wheatley SP, Carvalho A, Vagnarelli P, Earnshaw WC (2001). "INCENP is required for proper targeting of Survivin to the centromeres and the anaphase spindle during mitosis.". Curr. Biol. 11 (11): 886–90. doi:10.1016/S0960-9822(01)00238-X. PMID 11516652.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Parra MT, Viera A, Gómez R, et al. (2003). "Dynamic relocalization of the chromosomal passenger complex proteins inner centromere protein (INCENP) and aurora-B kinase during male mouse meiosis.". J. Cell. Sci. 116 (Pt 6): 961–74. doi:10.1242/jcs.00330. PMID 12584241.
Rangasamy D, Berven L, Ridgway P, Tremethick DJ (2003). "Pericentric heterochromatin becomes enriched with H2A.Z during early mammalian development.". Embo J. 22 (7): 1599–607. doi:10.1093/emboj/cdg160. PMID 12660166.
Honda R, Körner R, Nigg EA (2004). "Exploring the functional interactions between Aurora B, INCENP, and survivin in mitosis.". Mol. Biol. Cell 14 (8): 3325–41. doi:10.1091/mbc.E02-11-0769. PMID 12925766.
Wheatley SP, Henzing AJ, Dodson H, et al. (2004). "Aurora-B phosphorylation in vitro identifies a residue of survivin that is essential for its localization and binding to inner centromere protein (INCENP) in vivo.". J. Biol. Chem. 279 (7): 5655–60. doi:10.1074/jbc.M311299200. PMID 14610074.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gassmann R, Carvalho A, Henzing AJ, et al. (2004). "Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle.". J. Cell Biol. 166 (2): 179–91. doi:10.1083/jcb.200404001. PMID 15249581.
Li X, Sakashita G, Matsuzaki H, et al. (2004). "Direct association with inner centromere protein (INCENP) activates the novel chromosomal passenger protein, Aurora-C.". J. Biol. Chem. 279 (45): 47201–11. doi:10.1074/jbc.M403029200. PMID 15316025.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Zhu C, Bossy-Wetzel E, Jiang W (2005). "Recruitment of MKLP1 to the spindle midzone/midbody by INCENP is essential for midbody formation and completion of cytokinesis in human cells.". Biochem. J. 389 (Pt 2): 373–81. doi:10.1042/BJ20050097. PMID 15796717.
Chen HL, Tang CJ, Chen CY, Tang TK (2005). "Overexpression of an Aurora-C kinase-deficient mutant disrupts the Aurora-B/INCENP complex and induces polyploidy.". J. Biomed. Sci. 12 (2): 297–310. doi:10.1007/s11373-005-0980-0. PMID 15917996.
Vader G, Kauw JJ, Medema RH, Lens SM (2006). "Survivin mediates targeting of the chromosomal passenger complex to the centromere and midbody.". EMBO Rep. 7 (1): 85–92. doi:10.1038/sj.embor.7400562. PMID 16239925.
Goto H, Kiyono T, Tomono Y, et al. (2006). "Complex formation of Plk1 and INCENP required for metaphase-anaphase transition.". Nat. Cell Biol. 8 (2): 180–7. doi:10.1038/ncb1350. PMID 16378098.

This article on a gene on chromosome 11 is a stub. You can help Wikipedia by expanding it.

[pmid1860899-0] Earnshaw WC, Cooke CA (Sep 1991). "Analysis of the distribution of the INCENPs throughout mitosis reveals the existence of a pathway of structural changes in the chromosomes during metaphase and early events in cleavage furrow formation". J Cell Sci 98 ( Pt 4): 443–61. PMID 1860899.

[pmid11453556-1] Adams RR, Eckley DM, Vagnarelli P, Wheatley SP, Gerloff DL, Mackay AM, Svingen PA, Kaufmann SH, Earnshaw WC (Jul 2001). "Human INCENP colocalizes with the Aurora-B/AIRK2 kinase on chromosomes and is overexpressed in tumour cells". Chromosoma 110 (2): 65–74. PMID 11453556.

[entrez-2] "Entrez Gene: INCENP inner centromere protein antigens 135/155kDa". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3619.

[pmid12660166-3] Rangasamy, Danny; Berven Leise, Ridgway Patricia, Tremethick David John (Apr. 2003). "Pericentric heterochromatin becomes enriched with H2A.Z during early mammalian development". EMBO J. (England) 22 (7): 1599–607. doi:10.1093/emboj/cdg160. ISSN 0261-4189. PMID 12660166.

[pmid11516652-4] Wheatley, S P; Carvalho A, Vagnarelli P, Earnshaw W C (Jun. 2001). "INCENP is required for proper targeting of Survivin to the centromeres and the anaphase spindle during mitosis". Curr. Biol. (England) 11 (11): 886–90. ISSN 0960-9822. PMID 11516652.

[pmid15249581-5] Gassmann, Reto; Carvalho Ana, Henzing Alexander J, Ruchaud Sandrine, Hudson Damien F, Honda Reiko, Nigg Erich A, Gerloff Dietlind L, Earnshaw William C (Jul. 2004). "Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle". J. Cell Biol. (United States) 166 (2): 179–91. doi:10.1083/jcb.200404001. ISSN 0021-9525. PMID 15249581.

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