Interleukin 28 receptor, alpha subunit Information & Interleukin 28 receptor, alpha subunit Links at HealthHaven.com

Interleukin 28 receptor, alpha (interferon, lambda receptor)
Identifiers
Symbols	IL28RA; CRF2/12; IFNLR; IFNLR1; LICR2
External IDs	OMIM: 607404 MGI: 2429859 HomoloGene: 52086 GeneCards: IL28RA Gene
Gene ontology
Molecular function	• receptor activity; • interleukin receptor activity; • protein binding;
Cellular component	• membrane; • integral to membrane; • interleukin-28 receptor complex;
Biological process	• negative regulation of cell proliferation; • regulation of antiviral response by host;
Orthologs

edit

Interleukin 28 receptor, alpha subunit is a subunit for the interleukin-28 receptor. IL28RA is its human gene.

The protein encoded by this gene belongs to the class II cytokine receptor family. This protein forms a receptor complex with interleukine 10 receptor, beta (IL10RB). The receptor complex has been shown to interact with three closely related cytokines, including interleukin 28A (IL28A), interleukin 28B (IL28B), and interleukin 29 (IL29). The expression of all three cytokines can be induced by viral infection. The cells overexpressing this protein have been found to have enhanced responses to IL28A and IL29, but decreased response to IL28B. Three alternatively spliced transcript variants encoding distinct isoforms have been reported.^[1]

[edit] References

^ "Entrez Gene: IL28RA interleukin 28 receptor, alpha (interferon, lambda receptor)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=163702.

This article on a gene on chromosome 1 is a stub. You can help Wikipedia by expanding it.

[0] "Entrez Gene: IL28RA interleukin 28 receptor, alpha (interferon, lambda receptor)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=163702.

[1]