ICU may refer to:

• I.C.U. (film), an Australian thriller starring Christian Radford
• Intensive care unit, a specialized facility in a hospital that provides intensive care medicine
• International Components for Unicode, software libraries supporting internationalization
• Intersection Capacity Utilization, a measure of the capacity of a roadway intersection

Universities:

• Information and Communications University, a research university in Daejeon, South Korea
• International Christian University, a private university in Mitaka, Tokyo, Japan
• International Christian University - Kyiv, a private university in Kyiv, Ukraine
• Imperial College Union, the students union of Imperial College London

Politics:

• Industrial and Commercial Workers' Union, a South African political group from the 1920s
• International Clearing Union, a non-existent currency regulatory institution proposed in 1944
• Internationalist Communist Union, an international grouping of Trotskyist political parties
• Islamic Courts Union, an armed group of Sharia courts in Somalia

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