The International Classification of Diseases for Oncology (ICD-O) is a domain specific extension of the International Statistical Classification of Diseases and Related Health Problems for tumor diseases. This classification is widely used by cancer registries.

It is currently in its third revision (ICD-O-3). ICD-10 includes a list of morphology codes. They stem from ICD-O second edition (ICD-O-2) that was valid at the time of publication.

Contents 1 Axes 1.1 Morphology 1.1.1 Examples of codes (ICD-O-3) 1.1.1.1 (8000-8009) Not otherwise specified 1.1.1.2 (8010-8790) Epithelial 1.1.1.3 (8800-9370) Connective tissue 1.1.1.4 (9380-9589) Nervous system 1.1.1.5 (9590-9999) Hematologic (Leukemias, Lymphomas and related disorders) 1.1.1.6 -- Lymphoid leukemias, and related conditions 1.1.1.7 -- Myeloid leukemias, and related conditions 1.1.1.8 -- Other 1.2 Topography 2 See also 3 External links 3.1 Morphology

[edit] Axes

The classification has two axes:

[edit] Morphology

The morphology axis is for the morphology of the tumor.

This axis has additional importance, because the Systematized Nomenclature of Medicine(SNOMED) has adopted ICD-O's classification of morphology. SNOMED has been changing continuously, and several different versions of SNOMED are in use. Accordingly, mapping of ICD-O codes to SNOMED requires careful assessment whether entities really match, or not.

[edit] Examples of codes (ICD-O-3)

[edit] (8000-8009) Not otherwise specified

• (8000-8004) Neoplasms, NOS
  • (M8000/0) Neoplasm, benign
  • (M8000/1) Neoplasm, uncertain whether benign or malignant
  • (M8000/3) Neoplasm, malignant
  • (M8000/6) Neoplasm, metastatic
  • (M8000/9) Neoplasm, malignant, uncertain whether primary or metastatic

[edit] (8010-8790) Epithelial

• (8010-8040) Epithelial neoplasms, NOS
• (8050-8080) Squamous cell neoplasms
  • (M8070/3) Squamous cell carcinoma, NOS
• (8090-8110) Basal cell neoplasms
  • (M8090/3) Basal cell carcinoma, NOS
• (8120-8130) Transitional cell Papillomas And Carcinomas
• (8140-8380) Adenomas And Adenocarcinomas (glands)
  • (M8140/0) Adenoma, NOS
  • (M8140/3) Adenocarcinoma, NOS
  • (M8142/3) Linitis plastica
  • (M8151/0) Insulinoma, NOS
  • (M8152/0) Glucagonoma, NOS
  • (M8153/1) Gastrinoma, NOS
  • (M8155/3) Vipoma
  • (M8160/3) Cholangiocarcinoma
  • (M8170/3) Hepatocellular carcinoma, NOS
  • (M8200/3) Adenoid cystic carcinoma
  • (M8240/1) Carcinoid tumor, NOS, of appendix
  • (M8271/0) Prolactinoma
  • (M8290/0) Oncocytoma
  • (M8290/0) Hurthle cell adenoma
  • (M8312/3) Renal cell carcinoma
  • (M8312/3) Grawitz tumor
  • (M8360/1) Multiple endocrine adenomas
  • (M8380/0) Endometrioid adenoma, NOS
• (8390-8420) Adnexal And Skin appendage Neoplasms
• (8430-8439) Mucoepidermoid Neoplasms
• (8440-8490) Cystic, Mucinous And Serous Neoplasms
  • (M8440/0) Cystadenoma, NOS
  • (M8480/6) Pseudomyxoma peritonei
• (8500-8540) Ductal, Lobular And Medullary Neoplasms
• (8550-8559) Acinar cell neoplasms
• (8560-8580) Complex epithelial neoplasms
  • (M8561/0) Warthin's tumor
  • (M8580/0) Thymoma, NOS
• (8590-8670) Specialized gonadal neoplasms
  • (M8590/1) Sex cord-stromal tumor
  • (M8600/0) Thecoma, NOS
  • (M8620/1) Granulosa cell tumor, NOS
  • (M8630/1) Arrhenoblastoma, NOS
  • (M8631/0) Sertoli-Leydig cell tumor
• (8680-8710) Paragangliomas And Glomus tumors
  • (M8680/1) Paraganglioma, NOS
  • (M8700/0) Pheochromocytoma, NOS
  • (M8711/0) Glomus tumor
• (8720-8790) Nevi And Melanomas
  • (M8720/0) Melanocytic nevus
  • (M8720/3) Malignant melanoma, NOS
  • (M8720/3) Melanoma, NOS
  • (M8721/3) Nodular melanoma
  • (M8727/0) Dysplastic nevus
  • (M8742/3) Lentigo maligna melanoma
  • (M8743/3) Superficial spreading melanoma
  • (M8744/3) Acral lentiginous melanoma, malignant
  • (M8745/3) Melanoma, desmoplastic, amelanotic

[edit] (8800-9370) Connective tissue

• (8800-8809) Soft tissue Tumors And Sarcomas, Nos
  • (M8800/3) Sarcoma, NOS
  • (M8800/3) Soft tissue sarcoma
  • (M8806/3) Desmoplastic small round cell tumor

• (8810-8830) Fibromatous neoplasms
  • (M8810/0) Fibroma, NOS
  • (M8810/3) Fibrosarcoma, NOS

• (8840-8849) Myxomatous neoplasms
  • (M8840/0) Myxoma, NOS

• (8850-8880) Lipomatous neoplasms
  • (M8850/0) Lipoma, NOS
  • (M8850/3) Liposarcoma, NOS

• (8890-8920) Myomatous neoplasms
  • (M8890/0) Leiomyoma, NOS
  • (M8890/3) Leiomyosarcoma, NOS
  • (M8895/0) Myoma
  • (M8895/3) Myosarcoma
  • (M8900/0) Rhabdomyoma, NOS
  • (M8900/3) Rhabdomyosarcoma, NOS

• (8930-8990) Complex Mixed And Stromal Neoplasms
  • (M8940/0) Pleomorphic adenoma
  • (M8960/3) Nephroblastoma, NOS (Wilms's tumor)

• (9000-9030) Fibroepithelial Neoplasms
  • (M9000/0) Brenner tumor, NOS

• (9040-9049) Synovial-Like Neoplasms
  • (M9040/3) Synovial sarcoma, NOS

• (9050-9059) Mesothelial Neoplasms
  • (M9050/0) Mesothelioma, benign
  • (M9050/3) Mesothelioma, NOS

• (9060-9090) Germ cell Neoplasms
  • (M9060/3) Dysgerminoma
  • (M9064/3) Germ cell tumor, NOS
  • (M9070/3) Embryonal carcinoma, NOS
  • (M9071/3) Yolk sac tumor
  • (M9080/0) Teratoma, benign
  • (M9080/3) Teratoma, malignant, NOS
  • (M9084/0) Dermoid cyst, NOS

• (9100-9109) Trophoblastic neoplasms
  • (M9100/3) Choriocarcinoma, NOS

• (9110-9119) Mesonephromas
• (9120-9160) Blood vessel tumors
  • (M9120/0) Hemangioma, NOS
  • (M9120/0) Angioma, NOS
  • (M9120/3) Hemangiosarcoma
  • (M9120/3) Angiosarcoma
  • (M9130/0) Hemangioendothelioma, benign
  • (M9130/1) Hemangioendothelioma, NOS
  • (M9140/3) Kaposi's sarcoma
  • (M9150/0) Hemangiopericytoma, benign
  • (M9150/1) Hemangiopericytoma, NOS

• (9170-9179) Lymphatic vessel tumors
  • (M9170/0) Lymphangioma, NOS
  • (M9173/0) Cystic lymphangioma

• (9180-9240) Osseous And Chondromatous neoplasms
  • (M9180/0) Osteoma, NOS
  • (M9180/3) Osteosarcoma, NOS
  • (M9210/0) Osteochondroma
  • (M9210/0) Cartilaginous exostosis
  • (M9220/0) Chondroma, NOS
  • (M9220/3) Chondrosarcoma, NOS

• (9250-9259) Giant cell tumors
• (9260-9269) Miscellaneous bone tumors
  • (M9260/3) Ewing's sarcoma

• (9270-9340) Odontogenic tumors
  • (M9273/0) Cementoblastoma, benign
  • (M9310/0) Ameloblastoma, NOS

• (9350-9370) Miscellaneous tumors
  • (M9350/1) Craniopharyngioma

[edit] (9380-9589) Nervous system

• (9380-9480) Gliomas
  • (M9382/3) Mixed oligoastrocytoma
  • (M9391/3) Ependymoma, NOS
  • (M9400/3) Astrocytoma, NOS
    • (9421/3) Pilocytic astrocytoma
    • (9440/3) Glioblastoma multiforme
  • (M9450/3) Oligodendroglioma, NOS

• (9490-9520) Neuroepitheliomatous neoplasms
  • (M9500/3) Neuroblastoma, NOS
  • (M9510/3) Retinoblastoma

• (9530-9539) Meningiomas

• (9540-9570) Nerve sheath tumors
  • (M9540/0) Neurofibroma, NOS
  • (M9540/1) Neurofibromatosis, NOS
  • (M9560/0) Schwannoma, NOS
  • (M9560/0) Neurinoma
  • (M9560/0) Acoustic neuroma
  • (M9570/0) Neuroma, NOS

• (9580-9589) Granular cell tumors and Alveolar soft part sarcoma

[edit] (9590-9999) Hematologic (Leukemias, Lymphomas and related disorders)

• (9590-9599) Malignant lymphoma, NOS, Or diffuse
  • (M9590/3) Lymphoma, NOS
  • (M9591/3) Non-Hodgkin's lymphoma, NOS
  • (M9592/3) Lymphosarcoma, NOS

• (9650-9660) Hodgkin's disease
  • (M9650/3) Hodgkin's disease, NOS
  • (M9651/3) Lymphocyte-rich classical Hodgkin lymphoma
  • (M9652/3) Mixed cellularity classical Hodgkin lymphoma
  • (M9653/3) Lymphocyte-depleted classical Hodgkin lymphoma
  • (M9659/3) Nodular lymphocyte predominant Hodgkin lymphoma
  • (M9663/3) Nodular sclerosis classical Hodgkin lymphoma

• (9670-9680) Malignant lymphoma Specified Type, Diffuse Or Nos
  • (M9670/3) Small lymphocytic lymphoma
  • (M9671/3) Lymphoplasmacytic lymphoma
  • (M9673/3) Mantle cell lymphoma
  • (M9678/3) Primary effusion lymphoma
  • (M9679/3) Mediastinal (thymic) large cell lymphoma
  • (M9680/3) Diffuse large B-cell lymphoma or Intravascular large B-cell lymphoma
  • (M9687/3) Burkitt lymphoma
  • (M9689/3) Splenic marginal zone lymphoma

• (9690-9699) Malignant lymphoma, Follicular Or Nodular, With Or Without diffuse areas
  • (M9690/3) Follicular lymphoma
  • (M9698/3) Follicular lymphoma
  • (M9699/3) Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT-lymphoma)
  • (M9699/3) Nodal marginal zone B-cell lymphoma

• (9700-9709) Specified Cutaneous And Peripheral T-Cell Lymphomas
  • (M9700/3) Mycosis fungoides
  • (M9701/3) Sezary syndrome
  • (M9702/3) Peripheral T-cell lymphoma, unspecified
  • (M9705/3) Angioimmunoblastic T-cell lymphoma
  • (M9708/3) Subcutaneous panniculitis-like T-cell lymphoma

• (9710-9719) Other Specified Non-Hodgkin's lymphomas
  • (M9714/3) Anaplastic large cell lymphoma
  • (M9716/3) Hepatosplenic T-cell lymphoma
  • (M9717/3) Enteropathy type T-cell lymphoma
  • (M9718/1) Lymphomatoid papulosis
  • (M9718/3) Primary cutaneous anaplastic large cell lymphoma
  • (M9719/3) Extranodal NK/T cell lymphoma, nasal type

• (9720-9729) Other Lymphoreticular neoplasms
  • (M9727/3) Blastic NK cell lymphoma
  • (M9728/3) Lymphoma
  • (M9729/3) Lymphoma

• (9730-9739) Plasma cell tumors
  • (M9731/3) Plasmacytoma, NOS or Extramedullary plasmacytoma or Solitary plasmacytoma of bone
  • (M9732/3) Multiple myeloma or Plasma cell myeloma
  • (M9734/3) Extraosseous plasmacytoma

• (9740-9749) Mast cell Tumors
  • (M9740/1) Mastocytoma, NOS or Extracutaneous mastocytoma
  • (M9740/3) Mast cell sarcoma
  • (M9741/1) Malignant mastocytosis or Indolent systemic mastocytosis
  • (M9741/3) Aggressive systemic mastocytosis or Systemic mastocytosis with associated clonal, hematological non-mast cell lineage disease
  • (M9742/3) Mast cell leukemia
  • (M9751/1) Langerhans cell histiocytosis
  • (M9755/3) Histiocytic sarcoma
  • (M9756/3) Langerhans cell sarcoma
  • (M9757/3) Dendritic cell sarcoma, NOS or Interdigitating dendritic cell sarcoma/tumor
  • (M9758/3) Follicular dendritic cell sarcoma/tumor

• (9760-9769) Immunoproliferative diseases
  • (M9761/3) Waldenstrom macroglobulinemia
  • (M9766/1) Lymphomatoid granulomatosis

[edit] -- Lymphoid leukemias, and related conditions

• (9800-9809) Leukemias, NOS
  • (M9800/3) Leukemia, NOS
  • (M9805/3) Acute leukemia of ambiguous lineage
  • (M9801/3) Acute leukemia, NOS

• (9820-9829) Lymphoid leukemias
  • (M9820/3) Lymphocytic leukemia, NOS
  • (M9820/3) Lymphatic leukemia, NOS
  • (M9821/3) Acute lymphoblastic leukemia, NOS
  • (M9821/3) Acute lymphocytic leukemia
  • (M9823/3) Chronic lymphocytic leukemia
  • (M9826/3) Leukemia
  • (M9827/3) Adult T-cell leukemia/lymphoma

• (9830-9839) Plasma cell leukemia
  • (M9831/3) T-cell large granular lymphocytic leukemia
  • (M9833/3) B-cell prolymphocytic leukemia
  • (M9834/3) T-cell prolymphocytic leukemia
  • (M9835/3) Precursor cell lymphoblastic leukemia, NOS
  • (M9836/3) Precursor B lymphoblastic leukemia
  • (M9837/3) Precursor T lymphoblastic leukemia

[edit] -- Myeloid leukemias, and related conditions

• (9840-9849) Erythroleukemias (FAB-M6)
  • (M9840/3) Acute erythroid leukemia

• (9850-9859) Lymphosarcoma cell leukemia

• (9860-9869) Myeloid (Granulocytic) Leukemias
  • (M9860/3) Myeloid leukemia, NOS
  • (M9860/3) Myelogenous leukemia, NOS
  • (M9861/3) Acute myelogenous leukemia (FAB-M1,M2)
  • (M9863/3) Chronic myelogenous leukemia
  • (M9866/3) Acute promyelocytic leukemia (FAB-M3)
  • (M9866/3) Acute promyelocytic leukemia (AML with t(15;17)(q22;q12), PML-RARa and variants)
  • (M9867/3) Acute myelomonocytic leukemia (FAB-M4)

• (9870-9889) Basophilic leukemia and Eosinophilic leukemia
  • (M9870/3) Basophilic leukemia or Acute basophilic leukemia
  • (M9871/3) AML with inv(16)(p13q22) or t(16;16)(p13;q22), CBFb/MYH11 (FAB M4Eo)
  • (M9872/3) Acute myeloid leukemia, minimally differentiated (FAB type M0)
  • (M9873/3) Acute myeloid leukemia, without maturation (FAB type M1)
  • (M9874/3) Acute myeloid leukemia, with maturation (FAB M2)
  • (M9875/3) Chronic myelogenous leukemia
  • (M9876/3) Atypical chronic myelogenous leukemia
  • (M9880/3) Eosinophilic leukemia

• (9890-9899) Monocytic leukemias
  • (M9890/3) Monocytic leukemia, NOS (FAB-M5)
  • (M9891/3) Acute monoblastic and monocytic leukemia (FAB M5)
  • (M9895/3) Acute myeloid leukemia multilineage dysplasia
  • (M9896/3) AML with t(8;21)(q22;q22), AML1/ETO
  • (M9897/3) AML with 11q23 (MLL) abnormalities

• (9900-9948) Other Leukemias
  • (M9910/3) Acute megakaryoblastic leukemia (FAB-M7)
  • (M9920/3) Acute myeloid leukemia and myelodysplastic syndrome, therapy related
  • (M9930/3) Chloroma or Myeloid sarcoma
  • (M9931/3) Acute panmyelosis with myelofibrosis
  • (M9940/3) Hairy cell leukemia
  • (M9946/3) Juvenile myelomonocytic leukemia
  • (M9948/3) Aggressive NK cell leukemia

[edit] -- Other

• (9950-9970) Miscellaneous Myeloproliferative And Lymphoproliferative disorders
  • (M9950/3) Polycythemia vera
  • (M9960/1) Myeloproliferative disease, NOS
  • (M9961/3) Chronic idiopathic myelofibrosis
  • (M9962/3) Essential thrombocytemia
  • (M9963/3) Chronic neutrophilic leukemia
  • (M9964/3) Chronic eosinophilic leukemia / hypereosinophilic syndrome
  • (M9970/1) Post-transplant lymphoproliferative disorder, pleomorphic
  • (M9975/3) Chronic Myeloproliferative disease, unclassifiable
  • (M9975/3) Myelodysplastic / myeloproliferative diseases, unclassifiable

• (9980-9989) Myelodysplastic syndrome
  • (M9980/3) Chronic myelomonocytic leukemia or Refractory anemia
  • (M9982/3) Refractory anemia with ringed sideroblasts
  • (M9983/3) Refractory anemia with excess blasts
  • (M9985/3) Refractory cytopenia with multilineage dysplasia
  • (M9986/3) Myelodysplastic syndrome associated with isolated del(5q) chromosome abnormality
  • (M9989/3) Myelodysplastic syndrome, NOS

[edit] Topography

The topography axis is for the topographical codes of the tumor's site. It is standardized with the C section of ICD-10

There were no changes in the topography axis between ICD-O-2 and ICD-O-3.

See List of ICD-10 codes#.28C00-C97.29 Malignant Neoplasms for examples.

[edit] See also

• Medical classification

[edit] External links

• Official page at World Health Organization
• Tutorial at National Cancer Institute
• Overview at DIMDI
• Overview of multiple primaries at healthyarkansas.com (PPT)
• History of versions at National Cancer Institute

[edit] Morphology

• Cancer.gov - overview, includes link to Excel spreadsheet with codes at National Cancer Institute
• Overview at National Cancer Institute
• Word document - malignancies only at National Cancer Institute
• Overview at University hospital Gießen und Marburg
• Download table at DIMDI
• Codes at IARC
• 1st, 2nd, and 3rd editions at wolfbane.com
• List at The National Cancer Registry Ireland
• List at London School of Hygiene & Tropical Medicine

v • d • e Glandular and epithelial neoplasms (ICD-O 8010-8589) Epithelium Papilloma/carcinoma (8010-8139) Small cell carcinoma · Verrucous carcinoma · Squamous cell carcinoma · Basal cell carcinoma · Transitional cell carcinoma · Inverted papilloma Glands Adenomas/ adenocarcinomas (8140-8429) Gastrointestinal tract: Linitis plastica · Familial adenomatous polyposis pancreas (Insulinoma, Glucagonoma, Gastrinoma, VIPoma, Somatostatinoma) Cholangiocarcinoma · Klatskin tumor · Hepatocellular adenoma/Hepatocellular carcinoma Urogenital Renal cell carcinoma · Endometrioid tumor · Renal oncocytoma Endocrine Prolactinoma · Multiple endocrine neoplasia · Adrenocortical adenoma/Adrenocortical carcinoma · Hurthle cell Other/multiple Neuroendocrine tumor (Carcinoid) · Adenoid cystic carcinoma · Oncocytoma · Clear cell adenocarcinoma · Apudoma · Cylindroma · Papillary hidradenoma Adnexal and skin appendage (8390-8429) sweat gland (Hidrocystoma, Syringoma) · Syringocystadenoma papilliferum Cystic, mucinous, and serous (8440-8499) Cystic general Cystadenoma/Cystadenocarcinoma Mucinous Signet ring cell carcinoma (Krukenberg tumor) · Mucinous cystadenoma/Mucinous cystadenocarcinoma (Pseudomyxoma peritonei) · Mucoepidermoid carcinoma Serous Serous cystadenoma/Serous cystadenocarcinoma/Papillary serous cystadenocarcinoma Ductal, lobular, and medullary (8500-8549) Ductal carcinoma Mammary ductal carcinoma · Pancreatic ductal carcinoma · Comedocarcinoma · Paget's disease of the breast/Extramammary Paget's disease Lobular carcinoma Lobular carcinoma in situ · Invasive lobular carcinoma Medullary carcinoma Medullary carcinoma of the breast · Medullary thyroid cancer Acinar cell (8550-8559) Acinic cell carcinoma Other Complex epithelial (8560-8589) Warthin's tumor · Thymoma

v • d • e Gonadal tumors, paraganglioma, glomus, nevi and melanomas (ICD-O 8590-8799) Gonadal/ sex cord-gonadal stromal (8590-8679) sex cord (Granulosa cell tumour, Sertoli cell tumor) stroma (Thecoma, Leydig cell tumor) both (Sertoli-Leydig cell tumour, Luteoma) Paragangliomas And Glomus tumors (8680-8719) Neuroendocrine tumor: Paraganglioma (Pheochromocytoma) Vascular tissue neoplasm: Glomus tumor (Glomangiosarcoma) Nevi and melanomas (8720-8799) Nevi Melanocytic/pigmented nevus (Mongolian spot, Blue nevus, Nevus of Ota, Spitz nevus) location (Junctional nevus, Compound nevus) Halo nevus · Dysplastic nevus Melanomas (NE) Superficial spreading melanoma · Nodular melanoma · lentigo (Lentigo maligna/Lentigo maligna melanoma, Acral lentiginous melanoma)

v • d • e Connective/soft tissue tumors and sarcomas (ICD-O 8800-9059) (C45-C49/D17-D21, 171/214-215) Not otherwise specified (8800-8809) Soft tissue sarcoma · Desmoplastic small round cell tumor Connective tissue neoplasm Fibromatous (8810-8839) Fibroma/fibrosarcoma: Dermatofibrosarcoma · Dermatofibrosarcoma protuberans · Desmoplastic fibroma Histiocytoma/histiocytic sarcoma: Benign fibrous histiocytoma · Malignant fibrous histiocytoma Myxomatous (8840-8849) Myxoma/myxosarcoma · Angiomyxoma · Ossifying fibromyxoid tumour Fibroepithelial (9000-9039) Brenner tumour · Fibroadenoma · Phyllodes tumor Synovial-like (9040-9049) Synovial sarcoma · Clear-cell sarcoma Lipomatous (8850-8889) Lipoma/liposarcoma (Myelolipoma, Myxoid liposarcoma) · PEComa (Angiomyolipoma) Myomatous (8890-8929) general: Myoma/myosarcoma smooth muscle: Leiomyoma/leiomyosarcoma skeletal muscle: Rhabdomyoma/rhabdomyosarcoma: Embryonal rhabdomyosarcoma (Sarcoma botryoides) · Alveolar rhabdomyosarcoma Complex Mixed And Stromal (8930-8999) Adenomyoma · Pleomorphic adenoma · Mixed Müllerian tumor · Mesoblastic nephroma · Wilms' tumor · Rhabdoid tumour · Clear-cell sarcoma of the kidney · Hepatoblastoma · Pancreatoblastoma · Carcinosarcoma Mesothelial (9050-9059) Mesothelioma · Adenomatoid tumor muscle, DF+DRCT navs: anat/hist/physio, acquired myopathy/congenital myopathy/neoplasia, symptoms+signs/eponymous, proc muscle, DF+DRCT navs: anat/hist/physio, acquired myopathy/congenital myopathy/neoplasia, symptoms+signs/eponymous, proc

v • d • e Germ cell tumors (ICD-O 9060-9119) (C45-C49/D17-D21, 171/214-215) Germinomatous Germinoma (Seminoma, Dysgerminoma) Nongerminomatous Embryonal carcinoma Mesonephroma: Endodermal sinus tumor/Yolk sac tumor Teratoma: Fetus in fetu · Dermoid cyst · Struma ovarii Trophoblastic neoplasm: Gestational trophoblastic disease (Hydatidiform mole) · Choriocarcinoma Polyembryoma Gonadoblastoma

v • d • e Vascular tissue neoplasm (ICD-O 9120-9179) (C49/D18, 171/215) Blood Hemangioma/hemangiosarcoma · Blue rubber bleb nevus syndrome · Hemangioendothelioma (Infantile hemangioendothelioma) · Kaposi's sarcoma · Hemangiopericytoma · Angiokeratoma · Capillary hemangioma (Hemangioblastoma) · Cavernous hemangioma Lymphatic Lymphangioma/lymphangiosarcoma · PEComa (Lymphangioleiomyomatosis) · Cystic hygroma Either Angioma/angiosarcoma · Angiofibroma vascular navs: anat/physio/dev, noncongen/systemic vasculitis/congen/neoplasia, symptoms+signs/eponymous, proc lymphatic organ navs: anat, physio, lymphatic disease/splenic disease/thymus disorders/thymus neoplasia/vascular tumors, proc

v • d • e Connective tissue neoplasm: Osseous and Chondromatous tumors (ICD-O 9180-9269) (C40-C41/D16, 170/213) Diaphysis Myeloid Multiple myeloma Epithelial Adamantinoma PNET/Ewing family Ewing's sarcoma Metaphysis Osteoblast Osteoid osteoma · Osteoblastoma Osteoma/osteosarcoma Chondroblast Chondroma/ecchondroma/enchondroma (Enchondromatosis) · Chondrosarcoma (Mesenchymal chondrosarcoma, Myxoid chondrosarcoma) Osteochondroma (Osteochondromatosis) Chondromyxoid fibroma Fibrous Ossifying fibroma · Fibrosarcoma Epiphysis Chondroblast Chondroblastoma Myeloid Giant cell tumor of bone Other/ungrouped Notochord Chordoma bone and cartilage navs: anat/physio/dev, noncongen/congen/neoplasia, symptoms+signs/eponymous signs, proc

v • d • e Odontogenic tumors (ICD-O 9270-9349) Cementoblast Cementoblastoma · Cementoma Ameloblast Ameloblastoma Mixed/hamartoma Odontoma Other Adenomatoid odontogenic tumor tooth navs: anat/dev, disease/neoplasia, proc

v • d • e Nervous tissue tumors/nervous system neoplasm/Neuroectodermal tumor (ICD-O 9350-9589) (C70-C72/D32-D33, 191-192/225) Endocrine/ sellar (9350-9379) sellar: Craniopharyngioma · Pituicytoma other: Pinealoma CNS (9380-9539) Neuroepithelial (brain tumors, spinal tumors) Glioma Astrocyte Astrocytoma (Pilocytic astrocytoma, Glioblastoma multiforme) Oligodendrocyte Oligodendroglioma Ependyma Ependymoma · Subependymoma Choroid plexus Choroid plexus tumor (Choroid plexus papilloma, Choroid plexus carcinoma) Multiple/unknown Oligoastrocytoma · Gliomatosis cerebri · Gliosarcoma Mature neuron Ganglioneuroma: Ganglioglioma · Retinoblastoma · Neurocytoma · Dysembryoplastic neuroepithelial tumour · Lhermitte-Duclos disease PNET Neuroblastoma (Esthesioneuroblastoma, Ganglioneuroblastoma) · Medulloblastoma · Atypical teratoid rhabdoid tumor Meningiomas (meninges) Meningioma Hematopoietic Primary central nervous system lymphoma PNS: NST (9540-9579) cranial and paraspinal nerves: Neurofibroma (Neurofibrosarcoma, Neurofibromatosis) · Neurilemmoma/Schwannoma (Acoustic neuroma) · Malignant peripheral nerve sheath tumor note: not all brain tumors are of nervous tissue, and not all nervous tissue tumors are in the brain central nervous system navs: anat/physio/dev, noncongen/congen/neoplasia, symptoms+signs/eponymous, proc peripheral nervous system navs: anat/histo/physio/dev, noncongen PNS somatic/autonomic/congen/neoplasia, symptoms+signs/eponymous, proc

v • d • e Hematological malignancy/leukemia histology (ICD-O 9590-9989, C81-C96, 200-208) Lymphoid/Lymphoproliferative, Lymphomas/Lymphoid leukemias (9590-9739, 9800-9839) B cell (lymphoma, leukemia) (most CD19, CD20) By development/ marker TdT+ ALL (Precursor B acute lymphoblastic leukemia/lymphoma) CD5+ naive B cell (CLL/SLL) mantle zone (Mantle cell) CD22+ Prolymphocytic · CD11c (Hairy cell leukemia) CD79a+ germinal center/follicular B cell (Follicular, Burkitt's, GCB-DLBCL) marginal zone/marginal-zone B cell (Splenic marginal zone, MALT, Nodal marginal zone) RS (CD15+,CD30+) Classic Hodgkin's lymphoma (Nodular sclerosis) · CD20 (Nodular lymphocyte predominant Hodgkin's lymphoma) PCDs/PP (CD38+/CD138+) see immunoproliferative immunoglobulin disorders By infection KSHV (Primary effusion) · EBV (Lymphomatoid granulomatosis, Post-transplant lymphoproliferative disorder) · HIV (AIDS-related lymphoma) · Helicobacter pylori (MALT lymphoma) T/NK T cell (lymphoma, leukemia) (most CD3, CD4, CD8) By development/ marker TdT+: ALL (Precursor T acute lymphoblastic leukemia/lymphoma) prolymphocyte (Prolymphocytic) CD30+ (Anaplastic large cell, Lymphomatoid papulosis) By location/peripheral Cutaneous (Mycosis fungoides, Sézary's disease) · Hepatosplenic · Angioimmunoblastic · Enteropathy-associated T-cell lymphoma By infection HTLV-1 (Adult T-cell leukemia/lymphoma) NK cell/ (most CD56) Aggressive NK-cell leukemia · Blastic NK cell lymphoma T or NK EBV (Extranodal NK-T-cell lymphoma) · Large granular lymphocytic leukemia Lymphoid+myeloid Acute biphenotypic leukaemia Lymphocytosis Lymphoproliferative disorders (X-linked lymphoproliferative disease, Autoimmune lymphoproliferative syndrome) · Leukemoid reaction · Pseudolymphoma lymphocyte navs: cells/physio, immunodeficiency/immunoproliferative immunoglobulin/neoplasia, proc

v • d • e Myeloid Hematological malignancy/leukemia histology (ICD-O 9590-9989, C81-C96, 200-208) CFU-GM/ and other granulocytes CFU-GM Myelocyte AML: Acute myeloblastic leukemia (M0, M1, M2), APL/M3 MP (Chronic neutrophilic leukemia) Monocyte AML (AMoL/M5, Myeloid dendritic cell leukemia) CML (Philadelphia chromosome, Accelerated phase chronic myelogenous leukemia) Myelomonocyte AML (M4) MD-MP (Juvenile myelomonocytic leukemia, Chronic myelomonocytic leukemia) Other Histiocytosis CFU-Baso AML (Acute basophilic) CFU-Eos AML (Acute eosinophilic) MP (Chronic eosinophilic leukemia/Hypereosinophilic syndrome) MEP CFU-Meg AML (AMKL/M7) MP (Essential thrombocytosis) CFU-E AML (Erythroleukemia/M6) MP (Polycythemia vera) MD (Refractory anemia, Refractory anemia with excess of blasts, Chromosome 5q deletion syndrome, Sideroblastic anemia, Paroxysmal nocturnal hemoglobinuria, Refractory cytopenia with multilineage dysplasia) CFU-Mast Mastocytoma (Mast cell leukemia, Mast cell sarcoma, Systemic mastocytosis) Multiple/unknown AML (Acute panmyelosis with myelofibrosis, Myeloid sarcoma) · MP (Myelofibrosis) · Acute biphenotypic leukaemia myeloid navs: cells/physio, disease of RBCs+megakaryocytes/monocytes+granulocytes/neoplasia, symptoms+signs/eponymous