Hepatocellular adenoma Information & Hepatocellular adenoma Links at HealthHaven.com

Hepatocellular adenoma
	Classification and external resources
	; Micrograph of a hepatic adenoma (bottom of image). H&E stain.
ICD-O:	M8170/0
DiseasesDB	5726
eMedicine	med/48
MeSH	D018248

Hepatocellular adenoma, also hepatic adenoma, or rarely hepadenoma, is an uncommon benign liver tumor which is associated with the use of hormonal contraception with a high estrogen content.^[1] Patients taking higher potency hormones, patients of advanced age, or patients with prolonged duration of use have a significantly increased risk of developing hepatocellular adenomas.^[2]

[edit] Diagnosis

MRI is the most useful investigation in the diagnosis and work-up.^[3] . CT may also be used to diagnose hepatic adenomas.

Large hepatic adenomas have a tendency to rupture and bleed massively inside the abdomen.

[edit] Radiologic differential diagnosis

[edit] Pathologic diagnosis

Micrograph of a hepatic adenoma demonstrating a regular reticulin scaffold. Reticulin stain.

Hepatic adenoma are, typically, well-circumscribed nodules that consist of sheets of hepatocytes with a bubbly vacuolated cytoplasm. The hepatocytes are on a regular reticulin scaffold and less or equal to three cell thick.

The histologic diagnosis of hepatic adenomas can be aided by reticulin staining. In hepatic adenomas, the reticulin scaffold is preserved and hepatocytes do not form layers of four or more hepatocytes, as is seen in hepatocellular carcinoma.

[edit] Etiology

Ninety percent of hepatic adenomas arise in women aged 20-40, most of whom use oral contraceptives.

[edit] Related Conditions

Hepatic adenomas are related to glycogen storage diseases, type 1, as well as anabolic steroids.

[edit] Treatment

All hepatocellular adenoma should be surgically resected emergently, because of the risk of rupture causing bleeding and because they may contain malignant foci.^[4]

[edit] Additional images

Micrograph of hepatic adenoma. H&E stain.

Micrograph of hepatic adenoma. Reticulin stain.

[edit] References

^ Rooks J, Ory H, Ishak K, Strauss L, Greenspan J, Hill A, Tyler C (1979). "Epidemiology of hepatocellular adenoma. The role of oral contraceptive use.". JAMA 242 (7): 644–8. doi:10.1001/jama.242.7.644. PMID 221698.
^ "Hepatocellular Adenoma: eMedicine Gastroenterology". http://emedicine.medscape.com/article/170205-overview.
^ Hussain S, van den Bos I, Dwarkasing R, Kuiper J, den Hollander J (2006). "Hepatocellular adenoma: findings at state-of-the-art magnetic resonance imaging, ultrasound, computed tomography and pathologic analysis.". Eur Radiol 16 (9): 1873–86. doi:10.1007/s00330-006-0292-4. PMID 16708218.
^ Toso C, Majno P, Andres A, Rubbia-Brandt L, Berney T, Buhler L, Morel P, Mentha G (2005). "Management of hepatocellular adenoma: solitary-uncomplicated, multiple and ruptured tumors.". World J Gastroenterol 11 (36): 5691–5. PMID 16237767. Full text

[edit] External links

http://library.med.utah.edu/WebPath/NEOHTML/NEOPL021.html

This oncology article is a stub. You can help Wikipedia by expanding it.

[0] Rooks J, Ory H, Ishak K, Strauss L, Greenspan J, Hill A, Tyler C (1979). "Epidemiology of hepatocellular adenoma. The role of oral contraceptive use.". JAMA 242 (7): 644–8. doi:10.1001/jama.242.7.644. PMID 221698.

[urlHepatocellular_Adenoma:_eMedicine_Gastroenterology-1] "Hepatocellular Adenoma: eMedicine Gastroenterology". http://emedicine.medscape.com/article/170205-overview.

[2] Hussain S, van den Bos I, Dwarkasing R, Kuiper J, den Hollander J (2006). "Hepatocellular adenoma: findings at state-of-the-art magnetic resonance imaging, ultrasound, computed tomography and pathologic analysis.". Eur Radiol 16 (9): 1873–86. doi:10.1007/s00330-006-0292-4. PMID 16708218.

[3] Toso C, Majno P, Andres A, Rubbia-Brandt L, Berney T, Buhler L, Morel P, Mentha G (2005). "Management of hepatocellular adenoma: solitary-uncomplicated, multiple and ruptured tumors.". World J Gastroenterol 11 (36): 5691–5. PMID 16237767. Full text

[1]

[2]

[3]

[4]

Contents