Gram-positive bacterial infection refers to a disease caused by Gram-positive bacteria.

It is important to recognize that this class is defined morphologically (by the absence of a bacterial outer membrane), and not histologically (by a purple appearance when stained), though the two usually coincide.

For example, infections by Mycobacteria are included in this class, though tuberculosis requires a special Ziehl-Neelsen stain stain, and leprosy usually cannot even be cultured.

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