Gq alpha subunit Information & Gq alpha subunit Links at HealthHaven.com

guanine nucleotide binding protein (G protein), alpha 14
Identifiers
Symbol	GNA14
Entrez	9630
HUGO	4382
OMIM	604397
RefSeq	NM_004297
UniProt	O95837
Other data
Locus	Chr. 9 q21

guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
Identifiers
Symbol	GNA11
Entrez	2767
HUGO	4379
OMIM	139313
RefSeq	NM_002067
UniProt	P29992
Other data
Locus	Chr. 19 p13.3

guanine nucleotide binding protein (G protein), q polypeptide
Identifiers
Symbol	GNAQ
Entrez	2776
HUGO	4390
OMIM	600998
RefSeq	NM_002072
UniProt	P50148
Other data
Locus	Chr. 9 q21

guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
Identifiers
Symbol	GNA15
Entrez	2769
HUGO	4383
OMIM	139314
RefSeq	NM_002068
UniProt	P30679
Other data
Locus	Chr. 19 p13.3

G_q protein or G_q/11 is a heterotrimeric G protein subunit that activates phospholipase C (PLC). PLC in turn hydrolyzes Phosphatidylinositol 4,5-bisphosphate (PIP₂) to diacyl glycerol (DAG) and inositol triphosphate (IP₃) signal transduction pathway. DAG acts as a second messenger that activates Protein Kinase C (PKC) and IP₃ helps in phosphorylation of some proteins.

[edit] Function

G_q proteins are class of G proteins which work to activate phospholipase C (PLC), participating in a variety of cellular signaling pathways, including taste, manic depression, tumor promotion, etc.^[1]

The G_q protein works by activating PLC. PLC then cleaves a phospholipid. In the process, phosphatidylinositol 4,5-bisphosphate (PIP2) is cleaved into diacyl glycerol (DAG) and inositol 1,4,5-triphosphate (IP₃). DAG remains on bound to the membrane, and IP₃ is released as a soluble structure into the cytosol. IP₃ then diffuses through the cytosol to bind to IP₃ receptors, particular calcium channels in the endoplasmic reticulum (ER). These channels are specific to calcium and only allow the passage of calcium to move through. This causes the cytosolic concentration of Calcium to increase, causing a cascade of intracellular changes and activity.^[1]

Further reading:Calcium function in vertebrates

In addition, calcium and DAG together works to activate PKC, which goes on to phosphorylate other molecules, leading to altered cellular activity.^[1]

Further reading:function of protein kinase C

[edit] Examples of GPCR partners

From modulatory neurotransmitter receptors (amine receptors belonging to rhodopsin family), G_q is usually coupled to e.g. the G-protein coupled receptors:

5-HT₂ serotonergic receptors
α₁ (Alpha-1) adrenergic receptors
Calcitonin receptor
H₁ histamine receptor
Metabotropic glutamate receptor, Group I
M₁, M₃, and M₅ muscarinic receptors

[edit] Genes

GNAQ, GNA11, GNA14, GNA15

[edit] See also

Second messenger system

[edit] References

^ ^a ^b ^c Alberts B, Lewis J, Raff M, Roberts K, Walter P (2002). Molecular biology of the cell (4^th Edition ed.). New York: Garland Science. ISBN 0-8153-3218-1.

[edit] External links

MeSH Gq+protein

This biochemistry article is a stub. You can help Wikipedia by expanding it.

[alberts-0] Alberts B, Lewis J, Raff M, Roberts K, Walter P (2002). Molecular biology of the cell (4^th Edition ed.). New York: Garland Science. ISBN 0-8153-3218-1.

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