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George Cosmas Adyebo (1945 – November 19, 2000) was a Ugandan politician and economist. He became prime minister of Uganda on January 22, 1991 when prime minister Samson Kisekka became vice-president. Adyebo served as prime minister for nearly 4 years, until November 18, 1994. Six years later he died at the International Hospital in Kampala after a long illness.

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