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GRB2-related adaptor protein
Identifiers
Symbols	GRAP; MGC64880
External IDs	OMIM: 604330 MGI: 1918770 HomoloGene: 4822
Gene ontology
Molecular function	• SH3/SH2 adaptor activity;
Cellular component	• cytoplasm;
Biological process	• intracellular signaling cascade; • Ras protein signal transduction; • cell-cell signaling;
RNA expression pattern
	More reference expression data
Orthologs
XP_001132900 (protein)	XP_001005586 (protein)

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GRB2-related adapter protein is a protein that in humans is encoded by the GRAP gene.^[1]^[2]^[3]

This gene encodes a member of the GRB2/Sem5 (C. elegans homolog)/Drk (Drosophila homolog) family. This member functions as a cytoplasmic signaling protein which contains an SH2 domain flanked by two SH3 domains. The SH2 domain interacts with ligand-activated receptors for stem cell factor and erythropoietin, and facilitates the formation of a stable complex with the BCR-ABL oncoprotein. This protein also associates with the Ras guanine nucleotide exchange factor SOS1 (son of sevenless homolog 1) through its N-terminal SH3 domain.^[3]

[edit] Interactions

GRAP has been shown to interact with Linker of activated T cells.^[4]^[5]

[edit] References

^ Feng GS, Ouyang YB, Hu DP, Shi ZQ, Gentz R, Ni J (Jul 1996). "Grap is a novel SH3-SH2-SH3 adaptor protein that couples tyrosine kinases to the Ras pathway". J Biol Chem 271 (21): 12129-32. PMID 8647802.
^ Trub T, Frantz JD, Miyazaki M, Band H, Shoelson SE (Feb 1997). "The role of a lymphoid-restricted, Grb2-like SH3-SH2-SH3 protein in T cell receptor signaling". J Biol Chem 272 (2): 894-902. PMID 8995379.
^ ^a ^b "Entrez Gene: GRAP GRB2-related adaptor protein". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10750.
^ Zhang, W; Sloan-Lancaster J, Kitchen J, Trible R P, Samelson L E (Jan. 1998). "LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation". Cell (UNITED STATES) 92 (1): 83-92. ISSN 0092-8674. PMID 9489702.
^ Perez-Villar, Juan J; Whitney Gena S, Sitnick Mitchell T, Dunn Robert J, Venkatesan Srividhya, O'Day Kathleen, Schieven Gary L, Lin Tai-An, Kanner Steven B (Aug. 2002). "Phosphorylation of the linker for activation of T-cells by Itk promotes recruitment of Vav". Biochemistry (United States) 41 (34): 10732-40. ISSN 0006-2960. PMID 12186560.

[edit] Further reading

Welsh M, Songyang Z, Frantz JD, et al. (1998). "Stimulation through the T cell receptor leads to interactions between SHB and several signaling proteins.". Oncogene 16 (7): 891–901. doi:10.1038/sj.onc.1201607. PMID 9484780.
Zhang W, Sloan-Lancaster J, Kitchen J, et al. (1998). "LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation.". Cell 92 (1): 83–92. doi:10.1016/S0092-8674(00)80901-0. PMID 9489702.
Wenzel J, Sanzenbacher R, Ghadimi M, et al. (2002). "Multiple interactions of the cytosolic polyproline region of the CD95 ligand: hints for the reverse signal transduction capacity of a death factor.". FEBS Lett. 509 (2): 255–62. doi:10.1016/S0014-5793(01)03174-X. PMID 11741599.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Zhao C, Ma H, Bossy-Wetzel E, et al. (2003). "GC-GAP, a Rho family GTPase-activating protein that interacts with signaling adapters Gab1 and Gab2.". J. Biol. Chem. 278 (36): 34641–53. doi:10.1074/jbc.M304594200. PMID 12819203.
Shiraiwa H, Takei M, Yoshikawa T, et al. (2004). "Detection of Grb-2-related adaptor protein gene (GRAP) and peptide molecule in salivary glands of MRL/lpr mice and patients with Sjögren's syndrome.". J. Int. Med. Res. 32 (3): 284–91. PMID 15174222.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.

This article on a gene on chromosome 17 is a stub. You can help Wikipedia by expanding it.

[pmid8647802-0] Feng GS, Ouyang YB, Hu DP, Shi ZQ, Gentz R, Ni J (Jul 1996). "Grap is a novel SH3-SH2-SH3 adaptor protein that couples tyrosine kinases to the Ras pathway". J Biol Chem 271 (21): 12129-32. PMID 8647802.

[pmid8995379-1] Trub T, Frantz JD, Miyazaki M, Band H, Shoelson SE (Feb 1997). "The role of a lymphoid-restricted, Grb2-like SH3-SH2-SH3 protein in T cell receptor signaling". J Biol Chem 272 (2): 894-902. PMID 8995379.

[entrez-2] "Entrez Gene: GRAP GRB2-related adaptor protein". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10750.

[pmid9489702-3] Zhang, W; Sloan-Lancaster J, Kitchen J, Trible R P, Samelson L E (Jan. 1998). "LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation". Cell (UNITED STATES) 92 (1): 83-92. ISSN 0092-8674. PMID 9489702.

[pmid12186560-4] Perez-Villar, Juan J; Whitney Gena S, Sitnick Mitchell T, Dunn Robert J, Venkatesan Srividhya, O'Day Kathleen, Schieven Gary L, Lin Tai-An, Kanner Steven B (Aug. 2002). "Phosphorylation of the linker for activation of T-cells by Itk promotes recruitment of Vav". Biochemistry (United States) 41 (34): 10732-40. ISSN 0006-2960. PMID 12186560.

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