GMC may refer to: - General Motors, an American automobile manufacturing company
- Game Maker Community, the official forum of Game Maker, a game creation tool
- Ganglion mother cell, in the developing nervous system that divides once to produce two neurons
- General Medical Council, the UK regulatory body for the medical professions
- Generalized Method of Cells, a micromechanics theory
- Georgia Military College, in Milledgeville, Georgia, USA
- Giant Molecular Cloud or a dark nebula
- Global Management Challenge, a competition for university students
- Global Mission Church, in Bundang, South Korea
- Global motion compensation, an algorithm used by some video codecs
- Goa Medical College, a premiere medical college in Goa, India
- Gomal Medical College, a constituent medical college of Khyber Medical University
- Gospel Music Channel, a Christian music television channel
- Grant Medical College, the government medical college in Mumbai
- Greater Manchester County Council, the former upper-tier local authority for Greater Manchester, England
- Green Mountain College, a liberal arts college in Poultney, Vermont, USA
- Guwahati Municipal Corporation, the tier of local government in Guwahati
- Proto-Germanic (proto-Germanic) language
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