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G₂ phase is the third, final, and usually the shortest subphase during interphase within the cell cycle in which the cell undergoes a period of rapid growth to prepare for mitosis. It follows successful completion of DNA synthesis and chromosomal replication during the S phase, and occurs during a period of often four to five hours (for human cells). This far into interphase the nucleus is well defined, bound by a nuclear envelope and contains at least one nucleolus. Although chromosomes have been replicated they cannot yet be distinguished individually because they are still in the form of loosely packed chromatin fibers. The G₂ phase prepares the cell for mitosis (M phase) which is initiated by prophase.

At the end of this gap phase is a control checkpoint (G₂ checkpoint),a different Cdk-cyclin kinase complex (protein kinase) termed the M-phase promoting factor(MPF), to determine if the cell can proceed to enter M phase and divide. The G₂ checkpoint prevents cells from entering mitosis with DNA damaged since the last division, providing an opportunity for DNA repair and stopping the proliferation of damaged cells. Because the G₂ checkpoint helps to maintain genomic stability, it is an important focus in understanding the molecular causes of cancer.

v • d • e Cell cycle Interphase G1 phase · S phase · G2 phase M phase Mitosis (Preprophase · Prophase · Prometaphase · Metaphase · Anaphase · Telophase) · Cytokinesis Cell cycle checkpoints Restriction point · Spindle checkpoint · Postreplication checkpoint Other cellular phases G0 phase · Apoptosis

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