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Frederic E. Mohs (March 1, 1910 – July 2, 2002), a physician and general surgeon, developed the Mohs Micrographic Surgery technique (MMS) in 1938 to remove skin cancer lesions while he was still a medical student at the University of Wisconsin–Madison. The procedure is often considered the best method for treating certain types of skin cancer, with cure rate approaching 100%.

Frederic Edward Mohs was born in Burlington, Wisconsin. He died at his home in Madison, Wisconsin on July 2, 2002 at the age of 92.^[1] His father died when he was 3 months old, and the family moved to Madison, where his mother ran a boarding house. After first wanting to become a radio engineer, he switched to medical studies in college. Mohs began developing his treatment in the 1930s, experimenting on rats and other animals. The breakthrough came when he discovered that treating cancerous and surrounding rat tissue with zinc chloride allowed it to be removed surgically and examined under a microscope. He treated his first human patient on June 23, 1936. Mohs, who spent his working life at the University of Wisconsin, was a tireless advocate for the surgical procedure he had devised and taught it to doctors from all over the world. In 1943 he married Mary Ellen Reynolds, who died in 1995. He is survived by two sons, Frederic and Thomas, of Madison; and a daughter, Jane Shimming of Jupiter, Fla. ^[2][3]

Mohs first tried to publish his findings and encouraging surgeons to learn the practice. This was largely unsuccessful, as many surgeons are not comfortable learning skin pathology and laboratory techniques. Dermatologists, who are well trained in dermatopathology, and who treat skin cancers on a daily basis, quickly embraced the procedure. Today, most Mohs procedures are done by dermatologists, although a small number of plastic surgeons, otolaryngologists, and pathologists are also practicing and using the procedure as well.^[3]

Mohs' technique was later modified by Perry Robins in the 1970s, using fresh-tissue frozen histology. Rather than using the anesthetic Mohs paste, local anesthetic is used. The fresh skin specimen is then mounted on a cryostat, and frozen sections were examined instead of the mounting the Mohs paste fixed sections. This method is now commonly referred to as Mohs surgery, and occasionally chemosurgery, in reference to the Mohs paste Dr. Mohs initially used.

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