In nuclear strategy, first strike capability is a country's ability to defeat another nuclear power by destroying its arsenal to the point where the attacking country can survive the weakened retaliation.

First strike may also refer to:

• First Strike (Def Leppard album), an unreleased album recorded by Def Leppard in 1979, released in 1984
• "First Strike" (Stargate Atlantis), an episode of the TV series Stargate Atlantis
• Police Story 4: First Strike, AKA Jackie Chan's First Strike, a 1995 action movie
• Halo: First Strike, a 2003 novel written by Eric Nylund. It is based on the video game series
• First Strike Coins, the first coins struck from a new set of dies

This disambiguation page lists articles associated with the same title. If an internal link led you here, you may wish to change the link to point directly to the intended article.

• First Strike (Documentary) a 1979 documentary film about nuclear war.