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Fibrous dysplasia
Classification and external resources
ICD-10	K10.8, M85.0, Q78.1
ICD-9	526.89, 733.29, 756.54
MedlinePlus	001234
eMedicine	radio/284
MeSH	D005357

Fibrous dysplasia is a disease that causes bone thinning^[1] and growths or lesions in one or more bones, and leads to bone weakness and scar formation within the bones ^[2].

Contents 1 Presentation 2 Causes 3 See also 4 References 5 External links

[edit] Presentation

These lesions are tumor-like growths that consist of replacement of the medullary bone with fibrous tissue, causing the expansion and weakening of the areas of bone involved. Especially when involving the skull or facial bones, the lesions can cause externally visible deformities. The skull is often, but not necessarily, affected, and any other bone(s) can be involved.

• Many patients have lesions localized in only one bone (monostotic fibrous dysplasia), affecting 70-80%.
• Others have them in many bones (polyostotic fibrous dysplasia).

In 3% of cases, people suffering from fibrous dysplasia also have endocrine diseases and skin pigmentation; the three together constitute McCune-Albright syndrome. These endocrine diseases include precocious (early) puberty, often occurring as early as 6 years old.

[edit] Causes

Fibrous dysplasia is very rare; not much is known about it, and there is no known cure. The cause of the disease is unknown, but it is not hereditary.^[3] There are two types of fibrous dysplasia: 1. Monostotic (Involving a single bone), and 2. Polyostotic (Involving many bones). The most severe form of polystotic fibrous dysplasia is known as Albright Syndrome.

[edit] See also

• Cherubism
• Dysplasia

[edit] References

[edit] External links

• The Paget Foundation
• Duke Orthopedics fibrous_dysplasia
• Fibrous Dysplasia Pictures MedPix Imaging Database
• Fibrous Dysplasia of the Skull Images radRounds Radiology Image Database
• Fibrous Dysplasia Foundation
• MAGIC Foundation

v • d • e Osteochondropathy (M80-M94, 730-733) Osteopathies Osteitis endocrine bone disease: Osteitis fibrosa cystica (Brown tumor) infectious bone disease: Osteomyelitis (Sequestrum, Involucrum) · Sesamoiditis · Brodie abscess · Periostitis Bone density and structure Density / metabolic bone disease Osteoporosis · Osteopenia · Osteomalacia Continuity of bone Pseudarthrosis · Stress fracture Other Fibrous dysplasia (Monostotic, Polyostotic) · Skeletal fluorosis · bone cyst (Aneurysmal bone cyst) · Hyperostosis (Infantile cortical hyperostosis) · Osteosclerosis (Melorheostosis) Bone resorption Osteolysis · Hajdu-Cheney syndrome · Ainhum Ischemia Avascular necrosis Other Paget's disease of bone · Algoneurodystrophy · Hypertrophic pulmonary osteoarthropathy · Nonossifying fibroma Chondropathies Chondritis Relapsing polychondritis Other Tietze's syndrome Both Osteochondritis Osteochondritis dissecans Juvenile osteochondrosis lower limb: hip (Legg–Calvé–Perthes syndrome) · tibia (Osgood-Schlatter disease, Blount's disease) · foot (Köhler disease, Sever's disease) upper limb: wrist (Kienbock's disease) Bone and cartilage navboxes: anat / physio / dev, noncongen / congen / neoplasia, symptoms+signs / eponymous signs, proc

v • d • e Osteochondrodysplasia (Q77-Q78, 756.4-756.5) Osteodysplasia/ osteodystrophy Diaphysis Camurati-Engelmann disease/Engelmann syndrome Metaphysis Metaphyseal dysplasia · Jansen's metaphyseal chondrodysplasia · Schmid metaphyseal chondrodysplasia Epiphysis Spondyloepiphyseal dysplasia congenita · Multiple epiphyseal dysplasia · Otospondylomegaepiphyseal dysplasia Osteosclerosis Raine syndrome · Osteopoikilosis · Osteopetrosis Other/ungrouped FLNB (Boomerang dysplasia) · Polyostotic fibrous dysplasia (McCune-Albright syndrome) Chondrodysplasia/ chondrodystrophy (including dwarfism) Osteochondroma osteochondromatosis (Hereditary multiple exostoses) Chondroma/enchondroma enchondromatosis (Ollier disease, Maffucci syndrome) Growth factor receptor FGFR2: Antley-Bixler syndrome FGFR3: Achondroplasia (Hypochondroplasia) · Thanatophoric dysplasia COL2A1 collagen disease Achondrogenesis (type 2) · Hypochondrogenesis SLC26A2 sulfation defect Achondrogenesis (type 1B) · Recessive multiple epiphyseal dysplasia · Atelosteogenesis, type II · Diastrophic dysplasia Chondrodysplasia punctata Rhizomelic chondrodysplasia punctata · Conradi-Hünermann syndrome Other dwarfism Fibrochondrogenesis · Short rib-polydactyly syndrome (Majewski's polydactyly syndrome) · Léri-Weill dyschondrosteosis Bone and cartilage navboxes: anat / physio / dev, noncongen / congen / neoplasia, symptoms+signs / eponymous signs, proc