Fatty acid-binding protein Information & Fatty acid-binding protein Links at HealthHaven.com

The fatty-acid-binding proteins (FABPs) are a family of carrier proteins for fatty acids and other lipophilic substances such as eicosanoids and retinoids.^[1] These proteins are thought to facilitate the transfer of fatty acids between extra- and intracellular membranes.^[2] Some family members are also believed to transport lipophilic molecules from outer cell membrane to certain intracellular receptors such as PPAR.^[3]

[edit] Family members

Members of this family include:

Protein name	Gene	Tissue distribution	Comment
FABP 1	FABP1	liver
FABP 2	FABP2	intestinal
FABP 3	FABP3	muscle and heart	mammary-derived growth inhibitor
FABP 4	FABP4	adipocyte
FABP 5	FABP5	adipocyte	psoriasis-associated
FABP 6	FABP6	ileal	gastrotropin
FABP 7	FABP7	brain
FABP 8	PMP2	peripheral nervous system	peripheral myelin protein 2
FABP 9	FABP9	testis
FABP 11	fabp11	restricted to fishes
FABP 5-like 1	FABP5L1
FABP 5-like 2	FABP5L2
FABP 5-like 3	FABP5L3
FABP 5-like 4	FABP5L4
FABP 5-like 5	FABP5L5
FABP 5-like 6	FABP5L6
FABP 5-like 7	FABP5L7

[edit] References

^ Chmurzyńska A (2006). "The multigene family of fatty acid-binding proteins (FABPs): function, structure and polymorphism". J. Appl. Genet. 47 (1): 39–48. PMID 16424607. http://jag.igr.poznan.pl/2006-Volume-47/1/abstracts/313.html.
^ Weisiger RA (2002). "Cytosolic fatty acid binding proteins catalyze two distinct steps in intracellular transport of their ligands". Mol. Cell. Biochem. 239 (1-2): 35–43. doi:10.1023/A:1020550405578. PMID 12479566.
^ Tan NS, Shaw NS, Vinckenbosch N, Liu P, Yasmin R, Desvergne B, Wahli W, Noy N (2002). "Selective cooperation between fatty acid binding proteins and peroxisome proliferator-activated receptors in regulating transcription". Mol. Cell. Biol. 22 (14): 5114–27. doi:10.1128/MCB.22.14.5114-5127.2002. PMID 12077340.

[edit] External links

MeSH Fatty+Acid-Binding+Proteins

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[pmid16424607-0] Chmurzyńska A (2006). "The multigene family of fatty acid-binding proteins (FABPs): function, structure and polymorphism". J. Appl. Genet. 47 (1): 39–48. PMID 16424607. http://jag.igr.poznan.pl/2006-Volume-47/1/abstracts/313.html.

[pmid12479566-1] Weisiger RA (2002). "Cytosolic fatty acid binding proteins catalyze two distinct steps in intracellular transport of their ligands". Mol. Cell. Biochem. 239 (1-2): 35–43. doi:10.1023/A:1020550405578. PMID 12479566.

[pmid12077340-2] Tan NS, Shaw NS, Vinckenbosch N, Liu P, Yasmin R, Desvergne B, Wahli W, Noy N (2002). "Selective cooperation between fatty acid binding proteins and peroxisome proliferator-activated receptors in regulating transcription". Mol. Cell. Biol. 22 (14): 5114–27. doi:10.1128/MCB.22.14.5114-5127.2002. PMID 12077340.

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