F-box proteins are proteins containing at least one F-box motif, a protein structural motif of about 50 amino acids that mediates protein-protein interactions. The first identified F-box protein is one of three components of the SCF complex, which mediates ubiquitination of proteins targeted for degradation by the proteasome. The F-box motif interacts directly with the SCF protein Skp1^[1], and F-box motifs commonly exist in proteins in concert with other protein-protein interaction motifs such as leucine-rich repeats and WD repeats, which are thought to mediate interactions with SCF substrates ^[2].

F-box proteins have also been associated with cellular functions such as signal transduction and regulation of the cell cycle.^[3] In plants, many F-box proteins are represented in gene networks broadly regulated by microRNA-mediated gene silencing via RNA interference.^[4]

[edit] References

1. ^ Bai et al. (1996). "SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box.". Cell 86 (2): 263–74. 
2. ^ Kipreos ET, Pagano M. (2000). The F-box protein family. Genome Biol 1(5):REVIEWS3002. PMID 11178263
3. ^ Craig KL, Tyers M. (1999). The F-box: a new motif for ubiquitin dependent proteolysis in cell cycle regulation and signal transduction. Prog Biophys Mol Biol 72(3):299-328. PMID 10581972
4. ^ Jones-Rhoades M, Bartel D, Bartel B. "MicroRNAS and their regulatory roles in plants". Annu Rev Plant Biol 57: 19-53. PMID 16669754

[edit] External links

• MeSH F-Box+Proteins

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