Entactin Information & Entactin Links at HealthHaven.com

Nidogen 1
	PDB rendering based on 1gl4.
Available structures
	1gl4, 1h4u
Identifiers
Symbols	NID1; NID
External IDs	OMIM: 131390 MGI: 97342 HomoloGene: 1878
Gene ontology
Molecular function	• extracellular matrix structural constituent; • calcium ion binding; • protein binding;
Cellular component	• basement membrane; • membrane;
Biological process	• cell adhesion; • cell-matrix adhesion; • bioluminescence; • protein-chromophore linkage;
RNA expression pattern
	More reference expression data
Orthologs
NP_002499 (protein)	NP_035047 (protein)

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Entactin (or nidogen) is a component of the basement membrane alongside other components such as collagen type IV, proteoglycans ( heparan sulfate and glycosaminoglycans), laminin and fibronectin.

This gene encodes a member of the nidogen family of basement membrane glycoproteins. The protein interacts with several other components of basement membranes, and may play a role in cell interactions with the extracellular matrix.^[1]

[edit] Interactions

Entactin has been shown to interact with FBLN1.^[2]^[3]^[4]

[edit] References

^ "Entrez Gene: NID1 nidogen 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4811.
^ Adam, S; Göhring W, Wiedemann H, Chu M L, Timpl R, Kostka G (Sep. 1997). "Binding of fibulin-1 to nidogen depends on its C-terminal globular domain and a specific array of calcium-binding epidermal growth factor-like (EG) modules". J. Mol. Biol. (ENGLAND) 272 (2): 226–36. doi:10.1006/jmbi.1997.1244. ISSN 0022-2836. PMID 9299350.
^ Tran, H; VanDusen W J, Argraves W S (Sep. 1997). "The self-association and fibronectin-binding sites of fibulin-1 map to calcium-binding epidermal growth factor-like domains". J. Biol. Chem. (UNITED STATES) 272 (36): 22600–6. ISSN 0021-9258. PMID 9278415.
^ Pan, T C; Kluge M, Zhang R Z, Mayer U, Timpl R, Chu M L (Aug. 1993). "Sequence of extracellular mouse protein BM-90/fibulin and its calcium-dependent binding to other basement-membrane ligands". Eur. J. Biochem. (GERMANY) 215 (3): 733–40. ISSN 0014-2956. PMID 8354280.

[edit] Further reading

Chung AE, Durkin ME (1990). "Entactin: structure and function.". Am. J. Respir. Cell Mol. Biol. 3 (4): 275–82. PMID 2119632.
Yurchenco PD, Schittny JC (1990). "Molecular architecture of basement membranes.". FASEB J. 4 (6): 1577–90. PMID 2180767.

[edit] External links

MeSH Nidogen

This article on a gene on chromosome 1 is a stub. You can help Wikipedia by expanding it.

[0] "Entrez Gene: NID1 nidogen 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4811.

[pmid9299350-1] Adam, S; Göhring W, Wiedemann H, Chu M L, Timpl R, Kostka G (Sep. 1997). "Binding of fibulin-1 to nidogen depends on its C-terminal globular domain and a specific array of calcium-binding epidermal growth factor-like (EG) modules". J. Mol. Biol. (ENGLAND) 272 (2): 226–36. doi:10.1006/jmbi.1997.1244. ISSN 0022-2836. PMID 9299350.

[pmid9278415-2] Tran, H; VanDusen W J, Argraves W S (Sep. 1997). "The self-association and fibronectin-binding sites of fibulin-1 map to calcium-binding epidermal growth factor-like domains". J. Biol. Chem. (UNITED STATES) 272 (36): 22600–6. ISSN 0021-9258. PMID 9278415.

[pmid8354280-3] Pan, T C; Kluge M, Zhang R Z, Mayer U, Timpl R, Chu M L (Aug. 1993). "Sequence of extracellular mouse protein BM-90/fibulin and its calcium-dependent binding to other basement-membrane ligands". Eur. J. Biochem. (GERMANY) 215 (3): 733–40. ISSN 0014-2956. PMID 8354280.

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Contents

[edit] Interactions

[edit] References

[edit] Further reading

[edit] External links