Enovid (in the United States) or Enavid (in the United Kingdom) was the first combined oral contraceptive pill (COCP). Developed by G. D. Searle & Company, it was first made available in the U.S. in 1957. Initially Enovid was marketed only for the treatment of menstrual disorders. In 1960, the U.S. Food and Drug Administration approved an application to market it as a contraceptive.^[1] Just a few months later, in 1961, it was approved as a contraceptive in the UK.^[2]

Enovid was discontinued in 1988, along with other first-generation high-estrogen COCPs.^[3][4] Enovid consisted of 150 ug of mestranol and 9.58 mg of norethynodrel.

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