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Bas-relief from the Pilgrim Monument depicting the signing of the Mayflower Compact.

Edward Fuller (baptized 4 September 1575 in Redenhall, Norfolk County, England; died between 11 January and 10 April 1621 in Plymouth, Massachusetts) crossed the Atlantic on the Mayflower with his wife Ann and his 12-year-old son, Samuel, leaving a 15-year-old son Matthew in England (or Holland, where the Fullers had first gone in refuge from King James I).^{[citation needed]} Edward's brother Samuel, who was the Plymouth Colony doctor, and his wife, Bridget, were on the same Mayflower voyage, and both brothers, Edward and Samuel, signed the Mayflower Compact.

Both Edward and Ann died in the first winter in Plymouth, in early 1621, and their son Samuel was raised by his uncle Samuel and Bridget. Samuel Fuller, the MD, died in Plymouth, MA, in 1633. Edward's son Samuel lived until 1683. His son Matthew came from England to Massachusetts at some point, with a wife named Francis he married in 1630. Matthew died in Barnstable, MA, in 1678.^[1]

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