ESA, as a three letter abbreviation, can stand for: - East Side Access, a project to bring the Long Island Rail Road into Grand Central Terminal
- European Space Agency
- École Spéciale d'Architecture
- Ecole Superieure des Affaires, a Lebanese business school
- Ecological Society of America
- Education Savings Account, or Coverdell Education Savings Account
- EFTA Surveillance Authority
- Electronically Scanned Array
- Electric sonic amplitude, one of the electroacoustic phenomena in heterogeneous fluids
- Electrical Safety Authority, the electrical safety regulator of all buildings in Ontario, Canada
- Electrostatic analyzer, a component of ion optics
- Elliniki Stratiotiki Astinomia, the Greek Military Police
- El Salvador's IOC Country code
- Emergency Services Authority, Australian Capital Territory, Australia
- Emergency Stand Alone mode of distributed switching
- Employment and Support Allowance, a UK Government state benefit
- Employment Standards Act, an Act of Parliament in Canada
- Endangered Species Act, an important piece of US environmental legislation
- Energy Solutions Arena
- Entertainment Software Association
- Enthusiast System Architecture, a new technology platform for monitoring Nvidia motherboards and graphics cards
- Entomological Society of America
- Environmental Services Association, UK professional waste association
- Environmentally Significant Area, Canadian site designation
- Phase I Environmental Site Assessment
- Epsilon Sigma Alpha International, a women's service organization
- Epigraphic South Arabian script
- Episcopal School of Acadiana
- Erythropoiesis-Stimulating Agent
- The Etobicoke School of the Arts, a specialized arts school in Toronto, Ontario, Canada
- The European Atomic Energy Community Supply Agency, responsible for supply of nuclear fuels for European Community nuclear fuel users
- European Society for Agronomy
- European Sociological Association
- European Symposium on Algorithms
- European System of Accounts
- The End of Selected Area control code in the C1 control code set
- Evangelicals for Social Action
- Excited State Absorption
- The Raleigh Entertainment and Sports Arena, the former name of the RBC Center in Raleigh, North Carolina
- Embedded Systems and Applications, a major computer science Academic conference
- Esa, daughter of Etain, is a character from Irish mythology mentioned in the Banshenchas
- Esa (name), a common Finnish given name
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