Lidocaine/prilocaine Information & Lidocaine/prilocaine Links at HealthHaven.com

Lidocaine/prilocaine is a eutectic mixture of equal quantities (by weight) of lidocaine and prilocaine. A 5% emulsion preparation, containing 2.5% each of lidocaine/prilocaine, is marketed by APP Pharmaceuticals under the trade name EMLA (an abbreviation for Eutectic Mixture of Local Anesthetics)^[1]

[edit] Eutectic mixture

Separately, lidocaine and prilocaine are solid bases. When mixed together in equal quantities by weight, however, they form a eutectic mixture – that is the melting point of the mixture is lower than the melting points of the individual components. The lidocaine/prilocaine eutectic mixture is an oil with a melting point of 16°C, thus can be formulated into preparations without the use of a non-aqueous solvent ^[2]. This allows higher concentrations of anaesthetic to be formulated into the preparation and maintained during application.

[edit] Clinical use

[edit] Indications

The lidocaine/prilocaine combination is indicated for dermal anaesthesia. Specifically it is applied to prevent pain associated with intravenous catheter insertion, blood sampling, superficial surgical procedures; and topical anaesthesia of leg ulcers for cleansing or debridement ^[3]. Also, it can be used to numb the skin before tattooing as well as laser hair removal.

Researchers have shown that a new topical spray, consisting of an aerosol formulation of lidocaine and prilocaine, applied on the penile skin five minutes prior to intercourse is effective for treating premature ejaculation without adversely affecting the sensation of ejaculation.^[4]

[edit] Dosage forms

Lidocaine/prilocaine eutectic mixture is marketed as a 5% oil-in-water emulsion incorporated in a cream base (EMLA cream) or a cellulose disk (EMLA patch). The cream is applied under an occlusive dressing, while the patch incorporates an occlusive dressing to facilitate absorption of lidocaine and prilocaine into the area where anaesthesia is required. Local dermal anaesthesia is achieved after approximately 60 minutes, whereupon the occlusive dressing (or patch) is removed. The duration of anaesthesia is approximately two hours following removal of the occlusive dressing.

[edit] Emla Cream

EMLA (Eutectic Mixture of Lidocaine and Prilocaine) is a local anaesthetic for topical application, developed to anaesthetise intact skin. EMLA is used to prevent pain associated with needle insertion, intravenous cannulation, and superficial surgery on skin and genital mucous membrane. It can also be used to relieve and prevent pain associated with the cleansing and treatment of leg ulcers.

[edit] Toxicology

[edit] Compendial status

United States Pharmacopeia 31 ^[5]

[edit] Notes & References

Heinen MM, Achterberg T, Scholte op Reimer W, Kerkhof P, Laat E (2003) "Venous leg ulcer patients: a review of the literature on lifestyle and pain-related interventions" Journal of Clinical Nursing 13: 355-366

[edit] See also

[edit] References

^ http://www.medscape.com/viewarticle/704761_2
^ http://www.drugs.com/pro/emla.html
^ Template:(Heinen et al 2003)
^ http://www.auanet.org/content/press/press_releases/article.cfm?articleNo=120
^ The United States Pharmacopeial Convention. "Revision Bulletin: Lidocaine and Prilocaine Cream–Revision to Related Compounds Test". http://www.usp.org/USPNF/notices/lidocaineAndPrilocaine.html. Retrieved 10 July 2009.

[edit] External links

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[0] ttp://www.medscape.com/viewarticle/704761_2

[1] ttp://www.drugs.com/pro/emla.html

[2] Template:(Heinen et al 2003)

[3] ttp://www.auanet.org/content/press/press_releases/article.cfm?articleNo=120

[rblp-4] The United States Pharmacopeial Convention. "Revision Bulletin: Lidocaine and Prilocaine Cream–Revision to Related Compounds Test". http://www.usp.org/USPNF/notices/lidocaineAndPrilocaine.html. Retrieved 10 July 2009.

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