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Dressler's syndrome is a secondary form of pericarditis that occurs in the setting of injury to the heart or the pericardium (the outer lining of the heart). Dressler's syndrome is also known as postmyocardial infarction syndrome[1] and postcardiotomy pericarditis. It was first characterized by William Dressler in 1956.[2][3][4] It should not be confused with the Dressler's syndrome of haemoglobinuria named for Lucas Dressler, who characterized it in 1854.[5][6]
[edit] PresentationThe syndrome consists of a persistent low-grade fever, chest pain (usually pleuritic in nature), a pericardial friction rub, and /or a pericardial effusion. The symptoms tend to occur after a few weeks or even months after infarction and tend to subside in a few days. An elevated ESR is an objective laboratory finding. [edit] CausesIt is believed to result from an autoimmune inflammatory reaction to myocardial neo-antigens. Dressler's syndrome is associated with myocardial infarction (heart attack), and with heart surgery. [edit] Differential diagnosisIn the setting of myocardial infarction, Dressler's syndrome occurs in about 7% of cases,[7] and typically occurs 1 to 4 weeks after the myocardial infarction occurred, but may occur up to two years after the infract. This differentiates Dressler's syndrome from the much more common post myocardial infarction pericarditis that occurs in 17 to 25% of cases of acute myocardial infarction and occurs between days 2 and 4 after the infarction. Dressler's syndrome also needs to be differentiated from pulmonary embolism, another identifiable cause of pleuritic (and non-pleuritic) chest pain in people who have been hospitalized and/or undergone surgical procedures within the preceding weeks. [edit] TreatmentDressler's syndrome is typically treated with NSAIDs such as aspirin or with corticosteroids.[8] However coriticosteroids are reserved for rare cases and it is seldom required. It is largely a self limiting disease very rarely leads to pericardial tamponade. [edit] References
[edit] External links
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