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Domenico Gattilusio, Lord of Lesbos (died 1458) was the fifth ruler of an independent Lesbos from 1455 to 1458.

He was a son of Dorino of Lesbos and Orietta Doria. He succeeded his father and reigned in the island for three years.

He married Maria Giustiniani-Longo. They had no known children.

He was deposed by his younger brother Niccolò of Lesbos. His brother had him imprisoned and ordered his execution by the garrote.

Domenico of Lesbos
Born:  ? Died: 1458
Royal titles
Preceded by
Dorino
Lord of Lesbos
1455–1458
Succeeded by
Niccolo

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