Disopyramide

Systematic (IUPAC) name
4-(diisopropylamino)-2-phenyl-2-(pyridin-2-yl)butanamide
Identifiers
CAS number	3737-09-5
ATC code	C01BA03
PubChem	3114
DrugBank	APRD00507
ChemSpider	3002
Chemical data
Formula	C21H29N3O
Mol. mass	339.475 g/mol
SMILES	eMolecules & PubChem
Pharmacokinetic data
Bioavailability	High
Protein binding	50% to 65% (concentration-dependent)
Metabolism	Hepatic (CYP3A4-mediated)
Half life	6.7 hours (range 4 to 10 hours)
Excretion	Renal (80%)
Therapeutic considerations
Pregnancy cat.	B2(AU) C(US)
Legal status	POM(UK) ℞-only(US)
Routes	Oral, intravenous
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Disopyramide (INN, trade names Norpace and Rythmodan) is an antiarrhythmic medication. It is a Class Ia antiarrhythmic (sodium channel blocker) used in the treatment of ventricular tachycardias. It has no effect on alpha or beta adrenergic receptors. It resembles Quinidine but it has a marked anti-muscarinic effect on the heart, for this reason, it is not considered as a drug of 1st choice. It is also used in ventricular arrhythmia and supraventricular arrhythmia that might follow myocardial infarctions.

[edit] Cardiac Adverse Effects

• Acute heart failure[1]
• Severe hypotension

[edit] Extracardiac Effects

• Dry mouth
• Constipation
• Urinary retention
• Blurred vision
• Glaucoma
• Rash
• Agranulocytosis

[edit] External links

• Disopyramide on RxList

v • d • e Antiarrhythmic agents (C01B) Channel blockers class I (Na+ channel blockers) class Ia (Phase 0→ and Phase 3→) Procainamide # • Quinidine # • Ajmaline • Disopyramide • Prajmaline • Sparteine class Ib (Phase 3←) IV (Lidocaine #) • enteral (Mexiletine, Tocainide, Aprindine) class Ic (Phase 0→) Encainide • Flecainide • Lorcainide • Moricizine • Propafenone class III (Phase 3→, K+ channel blockers) Amiodarone • Bretylium • Bunaftine • Dofetilide • Ibutilide • Nifekalant • Sotalol • Tedisamil • E-4031 class IV (Phase 4→, Ca2+ channel blockers) Verapamil # • Diltiazem Receptor agonists and antagonists class II (Phase 4→, β blockers) Propranolol • Nadolol • Pindolol • cardioselective (Atenolol, Metoprolol, Acebutolol, Esmolol) A1 agonist Adenosine M2 muscarinic antagonist: Atropine • Quinidine • Disopyramide muscarinic agonist: Digoxin α receptors Quinidine • Verapamil • Amiodarone • Bretylium Ion transporters Na+ / K+-ATPase Digoxin # = WHO-EM

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