Diego Hurtado de Mendoza may refer to:

• Diego Hurtado de Mendoza (Admiral of Castile) (1367 – June 1404), Admiral of Castile and tenth head of the House of Mendoza
• Diego Hurtado de Mendoza, 1st Count of Melito (1468?–1536), military commander in Italian Wars & Revolt of the Brotherhoods; Viceroy of Valencia
• Diego Hurtado de Mendoza (poet and diplomat) (1503–1575), Spanish poet, novelist, historian, and diplomat
• Diego Hurtado de Mendoza y de la Cerda (died 1578), prince of Mélito; Viceroy of Catalonia, Viceroy & Lieutenant of Aragon

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