Desi may refer to:

• Desi, a self-referential term used by South Asian people
• Desi (raga), a raga in Indian classical music
• Desi an unrefined sugar in Pakistan.
• Desi or Druk Desi, a secular ruler of Bhutan
• Desi Arnaz, a Cuban-born musician, actor, comedian and television producer
• Desi Arnaz, Jr., an actor and musician
• Desi Relaford, a professional American baseball player
• Desidae, a family of spiders
• Desorption electrospray ionization, an ambient ionization technique for Mass Spectrometry
• DESI study, a German study to measure the ability of the German and English language of German students
• Drug Efficacy Study Implementation

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