deoxyribonuclease II alpha
Identifiers
Symbol	DNASE2
Alt. symbols	DNASE2A, DRN2, DNL, DNL2
Entrez	1777
HUGO	2960
OMIM	126350
RefSeq	NM_001375
UniProt	O00115
Other data
EC number	3.1.22.1
Locus	Chr. 19 p13.2

deoxyribonuclease II beta
Identifiers
Symbol	DNASE2B
Entrez	58511
HUGO	28875
OMIM	608057
RefSeq	NM_021233
UniProt	Q8WZ79
Other data
EC number	3.1.22.1
Locus	Chr. 1 p22.3

Deoxyribonuclease II, or Acid DNase, hydrolyzes deoxyribonucleotide linkages in native and denatured DNA yielding products with 3'-phosphates. As the name implies, it is more effective at acid pHs.

There are several known DNases II, including:

• DNase II alpha (usually just called DNase II)
• DNase II beta (also called DLAD, or DNase II-Like Acid DNase)

[edit] External links

• MeSH deoxyribonuclease+II

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v • d • e Hydrolase: esterases (EC 3.1) 3.1.1: Carboxylic ester hydrolases Cholinesterase (Acetylcholinesterase, Butyrylcholinesterase) · Pectinesterase · 6-phosphogluconolactonase · PAF acetylhydrolase Lipase (Bile salt dependent, Gastric/Lingual, Pancreatic, Lysosomal, Hormone-sensitive, Endothelial, Hepatic, Lipoprotein, Monoacylglycerol, Diacylglycerol) Phospholipase (A1, A2, B) 3.1.2: Thioesterase Palmitoyl thioesterase · Ubiquitin carboxy-terminal hydrolase L1 3.1.3: Phosphatase Alkaline phosphatase (ALPI, ALPL, ALPP) · Acid phosphatase (Prostatic)/Tartrate-resistant acid phosphatase/Purple acid phosphatases · Nucleotidase · Glucose 6-phosphatase · Fructose 1,6-bisphosphatase · Calcineurin · Phosphoprotein phosphatase (PP2A) · OCRL · Pyruvate dehydrogenase phosphatase · Fructose 6-P,2-kinase:fructose 2,6-bisphosphatase · Protein tyrosine phosphatase · PTEN · Phytase 3.1.4: Phosphodiesterase Autotaxin · Phospholipase (C, D) · Sphingomyelin phosphodiesterase (1) · PDE1 · PDE2 · PDE3 · PDE4A\PDE4B · PDE5 · Lecithinase (Clostridium perfringens alpha toxin) 3.1.6: Sulfatase arylsulfatase (Arylsulfatase A, Arylsulfatase B, Arylsulfatase E, Steroid sulfatase) · Galactosamine-6 sulfatase · Iduronate-2-sulfatase · N-acetylglucosamine-6-sulfatase Nuclease (includes deoxyribonuclease and ribonuclease) 3.1.11-16: Exonuclease Exodeoxyribonuclease RecBCD Exoribonuclease Oligonucleotidase 3.1.21-31: Endonuclease Endodeoxyribonuclease Deoxyribonuclease I · Deoxyribonuclease II · Deoxyribonuclease IV · Restriction enzyme · UvrABC endonuclease Endoribonuclease RNase III · RNase H (1, 2A, 2B, 2C) · RNase P · RNase A (1, 2, 3, 4/5) · RNase T1 · RNA-induced silencing complex either deoxy- or ribo- Aspergillus nuclease S1 · Micrococcal nuclease