Darier's sign is a change observed after stroking the skin of a person with systemic mastocytosis or urticaria pigmentosa.

In general, the skin becomes swollen, itchy and red. This is a result of compression of mast cells, which are hyperactive in these diseases. These mast cells release inflammatory granules which contain histamine. It is the histamine which is responsible for the response seen after rubbing the skin.

[edit] Eponym

Darier's sign is named after the French dermatologist Ferdinand-Jean Darier who first described it.^[1]

[edit] See also

• Dermatographic urticaria

[edit] References

v • d • e Eponymous medical signs for integumentary system Skin Asboe-Hansen sign - Auspitz's sign - Crowe sign - Darier's sign - Koebner's phenomenon - Leser-Trelat sign - Florid cutaneous papillomatosis - Nikolsky's sign - Wickham striae Nails Aldrich-Mees' lines - Beau's lines - Muehrcke's lines - Terry's nails integument, SF, LCT navs: anat/physio, noncongen/congen/neoplasia, symptoms+signs/eponymous, proc skin appendage navs: anat, noncongen/congen/neoplasia, symptoms+signs/eponymous, proc

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