N,N-Diisopropylethylamine
IUPAC name	Ethyldiisopropylamine
Other names	Hunig's base Diisopropylethylamine DIPEA EDIPA
Identifiers
CAS number	7087-68-5 Y
SMILES	CC(C)N(CC)C(C)C
Properties
Molecular formula	C8H19N
Molar mass	129.25 g/mol
Density	0.742 g/cm3
Melting point	< -50 °C
Boiling point	127 °C, 400 K, 261 °F
Hazards
MSDS	External MSDS
Y (what is this?)  (verify) Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

N,N-Diisopropylethylamine, or Hünig's base, DIPEA or DIEA, is an organic compound and an amine. It is used in organic chemistry as a base. Because the nitrogen atom is shielded by the two isopropyl groups and an ethyl group only a proton is small enough to easily fit. Just like 2,2,6,6-tetramethylpiperidine, this compound is a good base but a poor nucleophile which makes it a useful organic reagent.

Hunig's base is traditionally prepared by the reaction of diisopropylamine with diethyl sulfate.^[1]

Hünig's base forms a complex heterocyclic compound called scorpionine by a reaction with disulfur dichloride catalyzed by DABCO in a remarkable one-pot synthesis.^[2]

Hünig's base was investigated for its use as a selective reagent in the alkylation of secondary amines to tertiary amines by alkyl halides. This organic reaction is often hampered by a quaternization reaction to the quaternary ammonium salt but this side-reaction is absent when Hünig's base is present.^[3]

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