cysteine dioxygenase, type I
Identifiers
Symbol	CDO1
Entrez	1036
HUGO	1795
OMIM	603943
RefSeq	NM_001801
UniProt	Q16878
Other data
EC number	1.13.11.20
Locus	Chr. 5 q23.2

Cysteine dioxygenase (CDO,CAS number: 37256-59-0)) is a mammalian non-heme iron enzyme that catalyzes the conversion of L-cysteine to cysteine sulfinic acid (cysteine sulfinate) by incorporation of dioxygen.

Cysteine sulfinic acid lies at a branch-point in cysteine catabolism, where it can follow two pathways resulting in the formation of taurine or sulfate. The cysteine sulfinic acid-dependent pathway of taurine metabolism follows the synthesis of hypotaurine (2-aminoethane sulfinate), which is subsequently oxidized to taurine. Also, cysteine sulfinate can undergo transamination to form β-sulfinylpyruvate, decomposing to form pyruvate and sulfite.

[edit] References

• Sakakibara S, Yamaguchi K, Hosokawa Y, Kohashi N, Ueda I (February 1976). "Purification and some properties of rat liver cysteine oxidase (cysteine dioxygenase)". Biochim. Biophys. Acta 422 (2): 273–9. PMID 2307. 

• Chai SC, Jerkins AA, Banik JJ, et al (March 2005). "Heterologous expression, purification, and characterization of recombinant rat cysteine dioxygenase". J. Biol. Chem. 280 (11): 9865–9. doi:10.1074/jbc.M413733200. PMID 15623508. http://www.jbc.org/cgi/pmidlookup?view=long&pmid=15623508. 

• McCoy JG, Bailey LJ, Bitto E, et al (February 2006). "Structure and mechanism of mouse cysteine dioxygenase". Proc. Natl. Acad. Sci. U.S.A. 103 (9): 3084–9. doi:10.1073/pnas.0509262103. PMID 16492780. PMC 1413891. http://www.pnas.org/cgi/pmidlookup?view=long&pmid=16492780. 

This EC 1.13 enzyme-related article is a stub. You can help Wikipedia by expanding it. v • d • e

v • d • e Oxidoreductases: monooxygenases (EC 1.13) 1.13.11: two atoms of oxygen lipoxygenase: Arachidonate 5-lipoxygenase · Arachidonate 12-lipoxygenase/ALOX12 · Arachidonate 8-lipoxygenase · Arachidonate 15-lipoxygenase/ALOX15 · Linoleate 11-lipoxygenase other dioxygenase: Catechol dioxygenase · Homogentisate 1,2-dioxygenase · Cysteine dioxygenase · 4-Hydroxyphenylpyruvate dioxygenase · Indoleamine 2,3-dioxygenase 1.13.12: one atom of oxygen Firefly luciferase 1.13.99: other Inositol oxygenase

v • d • e Metabolism: amino acid metabolism · synthesis and catabolism enzymes (essential in CAPS) K→acetyl-CoA LYSINE→ Saccharopine dehydrogenase · Glutaryl-CoA dehydrogenase LEUCINE→ Branched chain aminotransferase · Branched-chain alpha-keto acid dehydrogenase complex · Isovaleryl coenzyme A dehydrogenase · Methylcrotonyl-CoA carboxylase · Methylglutaconyl-CoA hydratase · 3-hydroxy-3-methylglutaryl-CoA lyase TRYPTOPHAN→ Indoleamine 2,3-dioxygenase/Tryptophan 2,3-dioxygenase · Arylformamidase · Kynureninase · 3-hydroxyanthranilate oxidase · Aminocarboxymuconate-semialdehyde decarboxylase · Aminomuconate-semialdehyde dehydrogenase PHENYLALANINE→tyrosine→ (see below) G G→pyruvate →citrate glycine→serine→ Serine hydroxymethyltransferase · Serine dehydratase glycine→creatine: Guanidinoacetate N-methyltransferase · Creatine kinase alanine→ Alanine transaminase cysteine→ D-cysteine desulfhydrase threonine→ L-threonine dehydrogenase G→glutamate→ α-ketoglutarate HISTIDINE→ Histidine ammonia-lyase · Urocanate hydratase · Formiminotransferase cyclodeaminase proline→ Proline oxidase · Pyrroline-5-carboxylate reductase · 1-Pyrroline-5-carboxylate dehydrogenase/ALDH4A1 · PYCR1 arginine→ Ornithine aminotransferase · Ornithine decarboxylase · Agmatinase →alpha-ketoglutarate→TCA Glutamate dehydrogenase Other cysteine+glutamate→glutathione: Gamma-glutamylcysteine synthetase · Glutathione synthetase · Gamma-glutamyl transpeptidase glutamate→glutamine: Glutamine synthetase · Glutaminase G→propionyl-CoA→ succinyl-CoA VALINE→ Branched chain aminotransferase · Branched-chain alpha-keto acid dehydrogenase complex · Enoyl-CoA hydratase · 3-hydroxyisobutyryl-CoA hydrolase · 3-hydroxyisobutyrate dehydrogenase · Methylmalonate semialdehyde dehydrogenase ISOLEUCINE→ Branched chain aminotransferase · Branched-chain alpha-keto acid dehydrogenase complex · 3-hydroxy-2-methylbutyryl-CoA dehydrogenase METHIONINE→ generation of homocysteine: Methionine adenosyltransferase · Adenosylhomocysteinase regeneration of methionine: MTR/Homocysteine methyltransferase · Betaine-homocysteine methyltransferase conversion to cysteine: Cystathionine beta synthase · Cystathionine gamma-lyase THREONINE→ Threonine aldolase →succinyl-CoA→TCA Propionyl-CoA carboxylase · Methylmalonyl CoA epimerase · Methylmalonyl-CoA mutase G→fumarate PHENYLALANINE→tyrosine→ Phenylalanine hydroxylase · Tyrosine aminotransferase · 4-Hydroxyphenylpyruvate dioxygenase · Homogentisate 1,2-dioxygenase · Fumarylacetoacetate hydrolase tyrosine→melanin: Tyrosinase G→oxaloacetate asparagine→aspartate→ Asparaginase/Asparagine synthetase · Aspartate transaminase see also disorders, intermediates