Cutaneous T-cell lymphoma Information & Cutaneous T-cell lymphoma Links at HealthHaven.com

Cutaneous T cell lymphoma
	Classification and external resources
ICD-10	C84.0, C84.1
ICD-9	202.1, 202.2
ICD-O:	M9700/3, M9701/3
DiseasesDB	8595
eMedicine	med/3486
MeSH	D016410

"CTCL" redirects here. For the book by Loren Pope, see Colleges That Change Lives.

Cutaneous T cell lymphoma (CTCL) is a class of non-Hodgkin's lymphoma, which is a type of cancer of the immune system. Unlike most non-Hodgkin's lymphomas (which are generally B-cell related), CTCL is caused by a mutation of T cells. The malignant T cells in the body are pushed to the surface of the skin in a biological process used to rid the body of offending material, causing various lesions to appear on the skin. These lesions change shape as the disease progresses, typically beginning as what appears to be a rash and eventually forming plaques and tumors before metastasizing to other parts of the body.

[edit] Classification

Cutaneous T-cell lymphomas may be divided into the following types:^[1]^:727–740

[edit] Treatment

There is no cure for CTCL, but there are a variety of treatment options available and some CTCL patients are able to live somewhat normal lives with this cancer, although symptoms can be debilitating and painful, even in earlier stages.

FDA approved treatments are :^[2]

(1999) Denileukin diftitox (Ontak)
(2000) Bexarotene (Targretin) a retinoid
(2006) Vorinostat (Zolinza) a hydroxymate histone deacetylase (HDAC) inhibitor
(2009) Romidepsin (Istodax) a cyclic peptide histone deacetylase (HDAC) inhibitor

Other (off label) Treatments include:

Topical and oral corticosteroids
Bexarotene (Targretin) gel and capsules
Carmustine (Nitrogen Mustard)
Mechlorethamine
Phototherapy (Broad & Narrow Band UVB or PUVA)
Local & Total Skin Electron Beam Radiation
Conventional Radiation Therapy
Photopheresis
Interferons
Alemtuzumab (Campath-1H)
Methotrexate
Pentostatin and other purine analogues (Fludarabine, 2-deoxychloroadenosine)
Liposomal doxorubicin (Doxil)
Gemcitabine (Gemzar)
Cyclophosphamide
Bone marrow / stem cells
Allogenic transplantation

Other drugs are under investigation (for example panobinostat).

[edit] Epidemiology

Of all cancers involving the same class of blood cell, 2% of cases are cutaneous T cell lymphomas.^[3]

There is some evidence of a relationship with human T-lymphotropic virus.^[4]

[edit] See also

[edit] References

^ James, William D.; Berger, Timothy G.; et al. (2006). Andrews' Diseases of the Skin: clinical Dermatology. Saunders Elsevier. ISBN 0-7216-2921-0.
^ http://www.istockanalyst.com/article/viewnewspaged/articleid/3622028/pageid/1
^ Turgeon, Mary Louise (2005). Clinical hematology: theory and procedures. Hagerstown, MD: Lippincott Williams & Wilkins. p. 283. ISBN 0-7817-5007-5. "Frequency of lymphoid neoplasms. (Source: Modified from WHO Blue Book on Tumour of Hematopoietic and Lymphoid Tissues. 2001, p. 2001.)"
^ Nicot C (March 2005). "Current views in HTLV-I-associated adult T-cell leukemia/lymphoma". Am. J. Hematol. 78 (3): 232–9. doi:10.1002/ajh.20307. PMID 15726602. http://dx.doi.org/10.1002/ajh.20307.

[edit] External links

DermNet dermal-infiltrative/cutaneous-t-cell-lymphoma

Information on cutaneous T-cell lymphomas from Lymphoma Information Network
cutaneous T-cell lymphoma from H. Lee Moffitt Cancer Center & Research Institute
The Cutaneous Lymphoma Foundation

[Andrews-0] James, William D.; Berger, Timothy G.; et al. (2006). Andrews' Diseases of the Skin: clinical Dermatology. Saunders Elsevier. ISBN 0-7216-2921-0.

[1] ttp://www.istockanalyst.com/article/viewnewspaged/articleid/3622028/pageid/1

[isbn0-7817-5007-5-2] Turgeon, Mary Louise (2005). Clinical hematology: theory and procedures. Hagerstown, MD: Lippincott Williams & Wilkins. p. 283. ISBN 0-7817-5007-5. "Frequency of lymphoid neoplasms. (Source: Modified from WHO Blue Book on Tumour of Hematopoietic and Lymphoid Tissues. 2001, p. 2001.)"

[pmid15726602-3] Nicot C (March 2005). "Current views in HTLV-I-associated adult T-cell leukemia/lymphoma". Am. J. Hematol. 78 (3): 232–9. doi:10.1002/ajh.20307. PMID 15726602. http://dx.doi.org/10.1002/ajh.20307.

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