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Combined Injectable Contraceptive
Background
B.C. type	Hormonal
First use	about 1980
Failure rates (first year)
Perfect use	0-0.2%
Typical use	?
Usage
Duration effect	1 month
User reminders	?
Advantages and disadvantages
STD protection	No
Benefits	Especially good if poor pill compliance.

Combined injectable contraceptive (CIC) monthly injection of progesterone and estradiol taken to inhibit fertility. Brand names include Cyclofem, Novafem, Mesigyna, Lunelle.

[edit] History

October 5, 2000, Pharmacia received FDA approval for Lunelle Monthly Contraceptive Injection.^[1]
April 2003, Pharmacia acquired by Pfizer (makers of Depo-provera).
October 2003, Lunelle was discontinued in the U.S.

[edit] Use and packaging

Administered by intramuscular injection into the deltoid, gluteus maximus, or anterior thigh.^[1] Ideally administered every 28 to 30 days, though demonstrated to be effective up to 33 days.^[1]

[edit] Side-effects

The most prominent side effects are menstrual irregularities during the first 3 to 6 months of use.^[1]

[edit] Formulations

Lunelle contains medroxyprogesterone acetate (MPA) 25 mg plus estradiol cypionate (E2C) 5 mg.^[1]
Cyclofem contains depomedroxy-progesterone acetate (DMPA) 25 mg and estradiol cypionate 5 mg.
Mesigyna contains norethisterone enanthate (NET EN) 50 mg and estradiol valerate 5 mg.
Deladroxate contains dihydroxy-progesterone acetophenide 150 mg and estradiol enanthate 10 mg.

[edit] See also

[edit] Footnotes

^ ^a ^b ^c ^d ^e ^f "FDA Approves Combined Monthly Injectable Contraceptive". Contraception Report 12 (3). 2001. http://www.contraceptiononline.org/contrareport/article01.cfm?art=176.

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[contrareportFDAAproveLunelle-0] ^ ^a ^b ^c ^d ^e ^f "FDA Approves Combined Monthly Injectable Contraceptive". Contraception Report 12 (3). 2001. http://www.contraceptiononline.org/contrareport/article01.cfm?art=176.

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