City Center can refer to:
- Central business district or downtown
- City-Center, a 1960s redevelopment plan for Helsinki that was largely not acted upon
- City Center District, Dallas, Texas, a neighborhood in Dallas
- City Center, Miami Beach, Florida, a neighborhood in the City of Miami Beach
- CityCenter, a multi-building project under construction on the Las Vegas Strip
- Columbus City Center, a shopping mall in Columbus, Ohio
- New York City Center, a concert hall in New York City
- Oakland City Center, an office, shopping, residential, and hotel complex in Oakland, California
- Oyster Point City Center, a business district in Newport News, Virginia
- Deira City Centre, a shopping mall located in Dubai, United Arab Emirates