City Center can refer to:

• Central business district or downtown
• City-Center, a 1960s redevelopment plan for Helsinki that was largely not acted upon
• City Center District, Dallas, Texas, a neighborhood in Dallas
• City Center, Miami Beach, Florida, a neighborhood in the City of Miami Beach
• CityCenter, a multi-building project under construction on the Las Vegas Strip
• Columbus City Center, a shopping mall in Columbus, Ohio
• New York City Center, a concert hall in New York City
• Oakland City Center, an office, shopping, residential, and hotel complex in Oakland, California
• Oyster Point City Center, a business district in Newport News, Virginia
• Deira City Centre, a shopping mall located in Dubai, United Arab Emirates

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