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Cinchocaine

Systematic (IUPAC) name
2-butoxy-N-[2-(diethylamino)ethyl]quinoline-4-carboxamide
Identifiers
CAS number	85-79-0
ATC code	C05AD04 D04AB02 N01BB06 S01HA06
PubChem	3025
DrugBank	APRD00915
ChemSpider	2917
Chemical data
Formula	C20H29N3O2
Mol. mass	343.463 g/mol
SMILES	eMolecules & PubChem
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	topical, intravenous (equine euthanasia)
Y(what is this?)  (verify)

Cinchocaine (or Dibucaine) is an amide local anesthetic. It is the active ingredient in some topical hemorrhoid creams such as Proctosedyl. It is sold under the brand names Cincain, Nupercainal, Nupercaine and Sovcaine [1].

Dibucaine is insoluble in alkaline aquatic enviromends.

It is also a component of the veterinary drug Somulose, used for euthanasia of horses and cattle.

[edit] External links

• Abdel-Ghani N, Youssef A, Awady M (2005). "Cinchocaine hydrochloride determination by atomic absorption spectrometry and spectrophotometry.". Farmaco 60 (5): 419–24. doi:10.1016/j.farmac.2005.03.001. PMID 15910814. 
• Souto-Padron T, Lima AP, de Oliveira Ribeiro R. (2006). "Effects of dibucaine on the endocytic/exocytic pathways in Trypanosoma cruzi.". Parasitol Res 99: 317. doi:10.1007/s00436-006-0192-1. PMID 16612626. 
• Nounou M, El-Khordagui L, Khalafallah N. "Effect of various formulation variables on the encapsulation and stability of dibucaine base in multilamellar vesicles.". Acta Pol Pharm 62 (5): 369–79. PMID 16459486. 
• Aroti,A.;Leontidis, E. (2001). Journal of Chemical Education 76: 786-788. 

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