Cholecystokinin receptors or CCK receptors are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin.[1] There are two different subtypes CCKA and CCKB which are ~50% homologous:[2] Various cholecystokinin antagonists have been developed and are used in research, although the only drug of this class that has been widely marketed to date is the anti-ulcer drug proglumide. | protein | gene | tissue distribution | preferred ligand | function | | CCKA (CCK1) | CCKAR | primarily gastrointestinal tract, lesser amounts in the CNS | sulfated CCK >> nonsulfated CCK ≈ nonsulfated CCK | stimulation of bicarb secretion, gall bladder emptying and inhibiting gut motility | | CCKB (CCK2) | CCKBR | primarily CNS, lesser amounts in the gastrointestinal track | gastrin ≈ CCK (receptor does not descriminate between sulfated and nonsulfated peptides) | regulation of nociception, anxiety, memory and hunger | [edit] References - ^ Noble F, Wank SA, Crawley JN, Bradwejn J, Seroogy KB, Hamon M, Roques BP (1999). "International Union of Pharmacology. XXI. Structure, distribution, and functions of cholecystokinin receptors". Pharmacol. Rev. 51 (4): 745–81. PMID 10581329. http://pharmrev.aspetjournals.org/cgi/content/abstract/51/4/745.
- ^ Dufresne M, Seva C, Fourmy D (2006). "Cholecystokinin and gastrin receptors". Physiol. Rev. 86 (3): 805–47. doi:10.1152/physrev.00014.2005. PMID 16816139.
[edit] External links | Transmembrane receptor: G protein-coupled receptors | | | Class A: Rhodopsin like | | | | | | | | | | | | | | | GPR ( 1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182) | | | | Adenosine ( A1, A2A, A2B, A3) · P2Y ( 1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14) | | | | | | | Other | Acetylcholine ( M1, M2, M3, M4, M5) · Adrenomedullin · Anaphylatoxin ( C3a, C5a) · Angiotensin ( 1, 2) · Apelin · Bile acid · Bombesin ( BRS3, GRPR, NMBR) · Bradykinin ( B1, B2) · Cannabinoid ( CB1, CB2) · Chemokine · Cholecystokinin ( A, B) · Dopamine ( D1, D2, D3, D4, D5) · EBI2 · Endothelin ( A, B) · Estrogen · Formyl peptide ( 1, 2, 3) · Free fatty acid ( 1, 2, 3, 4) · FSH · Galanin ( 1, 2, 3) · Gonadotropin-releasing hormone ( 1, 2) · GHB receptor · Ghrelin · Histamine ( H1, H2, H3, H4) · Kisspeptin · Luteinizing hormone/choriogonadotropin · lysophosphatidic acid ( 1, 2, 3) · Lysophospholipid ( 1, 2, 3, 4, 5, 6, 7, 8) · MAS ( 1, 1L, D, E, F, G, X1, X2, X3, X4) · Melanocortin ( 1, 2, 3, 4, 5) · MCHR ( 1, 2) · Melatonin ( 1A, 1B, 1C) · Niacin ( 1, 2) · Motilin · Opioid ( Delta, Kappa, Mu, Nociceptin & Zeta, but not Sigma) · Olfactory · Opsin ( 3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) · Orexin ( 1, 2) · Oxytocin · Oxoglutarate · PAF · Prokineticin ( 1, 2) · Prolactin-releasing peptide · Protease-activated ( 1, 2, 3, 4) · Relaxin ( 1, 2, 3, 4) · Somatostatin ( 1, 2, 3, 4, 5) · Sphingosine-1-phosphate ( 1, 2, 3, 4, 5) · SREB · Succinate · TAAR ( 1, 2, 3, 5, 6, 8, 9) · Tachykinin ( 1, 2, 3) · Thyrotropin · Thyrotropin-releasing hormone · Urotensin-II · Vasopressin ( 1A, 1B, 2) | | | | Class B: Secretin like | | | GPR ( 56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 157) | | | Other | Brain-specific angiogenesis inhibitor ( 1, 2, 3) · Cadherin ( 1, 2, 3) · Calcitonin · CALCRL · CD97 · Corticotropin-releasing hormone ( 1, 2) · EMR ( 1, 2, 3) · Glucagon ( GR, GIPR, GLP1R, GLP2R) · Growth hormone releasing hormone · PACAPR1 · GPR · Latrophilin ( 1, 2, 3, ELTD1) · Methuselah-like proteins · Parathyroid hormone ( 1, 2) · Secretin · Vasoactive intestinal peptide ( 1, 2) | | | Class C: Metabotropic
glutamate / pheromone | | | TAS1R ( 1, 2, 3) · TAS2R ( 1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50) | | | Other | Calcium-sensing receptor · GABA B ( 1, 2) · Glutamate receptor ( Metabotropic glutamate ( 1, 2, 3, 4, 5, 6, 7, 8)) · GPRC6A · GPR ( 156, 158, 179) · RAIG ( 1, 2, 3, 4) | | | | Frizzled / Smoothened | | | |
