Chlortetracycline

Systematic (IUPAC) name
(4S,4aS,5aS,6S,12aS,Z)-2-[amino(hydroxy)methylene]-7-chloro-4-(dimethylamino)-6,10,11,12a-tetrahydroxy-6-methyl-4a,5,5a,6-tetrahydrotetracene-1,3,12(2H,4H,12aH)-trione
Identifiers
CAS number	57-62-5
ATC code	A01AB21 D06AA02 J01AA03 S01AA02 QJ51AA03
PubChem	5280963
ChemSpider	10469370
Chemical data
Formula	C22H23ClN2O8
Mol. mass	478.88 g/mol
SMILES	eMolecules & PubChem
Pharmacokinetic data
Bioavailability	30%
Protein binding	50 to 55%
Metabolism	Hepatic (75%)
Half life	5.6 to 9 hours
Excretion	Renal and biliary
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	Oral, IV, topical
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Chlortetracycline (trade name Aureomycin, Lederle) is a tetracycline antibiotic, and was the first tetracycline to be discovered. It was discovered in 1945 by Dr Benjamin Duggar in a soil sample from Sanborn Field at the University of Missouri, yielding an actinomycete, Streptomyces aureofaciens (hence the name Aureomycin). In veterinary medicine, it is commonly used to treat conjunctivitis in cats.^[1]

[edit] References

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