Chemotherapy regimens are often identified with acronyms, identifying the agents used in combination. Unfortunately, the letters used are not consistent across regimens, and in some cases (for example, "BEACOPP") the same letter is used to represent two different treatments. Because of this, there is not a naming standard for chemotherapy regimens, and this page merely represents commonly used conventions. A fundamental principle of combination cancer therapy is that different drugs work through different cytotoxic mechanisms. Because they have different dose-limiting adverse effects, they can be given together at full doses.[1] The term "Induction regimens" refers to a chemotherapy regimen which is used for the initial treatment of a disease. | Name | Components | Example of uses, and other notes | | ABVD | Adriamycin (doxorubicin), bleomycin, vinblastine, dacarbazine | Hodgkin's lymphoma | | AC | Adriamycin (doxorubicin), cyclophosphamide | Breast cancer | | BEACOPP | Bleomycin, etoposide, Adriamycin (doxorubicin), cyclophosphamide, Oncovin (vincristine), procarbazine, prednisone | Hodgkin's lymphoma | | BEP | Bleomycin, etoposide, platinum agent (cisplatin) | Testicular cancer, germ cell tumors | | CA | Cyclophosphamide, Adriamycin (doxorubicin) (same as AC) | Breast cancer | | CAF | Cyclophosphamide, Adriamycin (doxorubicin), fluorouracil (5-FU) | Breast cancer | | CAV | Cyclophosphamide, Adriamycin (doxorubicin), vincristine | Lung cancer | | CBV | Cyclophosphamide, BCNU (carmustine), VP-16 (etoposide) | Lymphoma | | ChlVPP/EVA | Chlorambucil, vincristine (Oncovin), procarbazine, prednisone, etoposide, vinblastine, Adriamycin (doxorubicin) | Hodgkin's lymphoma | | CHOP | Cyclophosphamide, hydroxydoxorubicin (doxorubicin), vincristine (Oncovin), prednisone | Non-Hodgkin lymphoma | | CHOP-R or R-CHOP | CHOP + rituximab | B cell non-Hodgkin lymphoma | | COP or CVP | Cyclophosphamide, Oncovin (vincristine), prednisone | Non-Hodgkin lymphoma in patients with history of cardiovascular disease | | CMF | Cyclophosphamide, methotrexate, fluorouracil (5-FU) | Breast cancer | | COPP | Cyclophosphamide, Oncovin (vincristine), procarbazine, prednisone | Non-Hodgkin lymphoma | | EC | Epirubicin, cyclophosphamide | Breast cancer | | ECF | Epirubicin, cisplatin, fluorouracil (5-FU) | Gastric cancer and oesophageal cancer | | EP | Etoposide, platinum agent (cisplatin) | Testicular cancer, germ cell tumors | | FEC | Fluorouracil (5-FU), epirubicin, cyclophosphamide | Breast cancer | | FL (Also known as Mayo) | Fluorouracil (5-FU), leucovorin (folinic acid) | Colorectal cancer | | FOLFOX | Fluorouracil (5-FU), leucovorin (folinic acid), oxaliplatin | Colorectal cancer | | FOLFIRI | Fluorouracil (5-FU), leucovorin (folinic acid), irinotecan | Colorectal cancer | | ICE | ifosfamide, carboplatin, etoposide (VP-16) | Aggressive lymphomas, progessive neuroblastoma | | ICE-R | ICE + rituximab | High-risk progressive or recurrent lymphomas | | m-BACOD | Methotrexate, bleomycin, Adriamycin (doxorubicin), cyclophosphamide, Oncovin (vincristine), dexamethasone | Non-Hodgkin lymphoma | | MACOP-B | Methotrexate, leucovorin (folinic acid), Adriamycin (doxorubicin), cyclophosphamide, Oncovin (vincristine), prednisone, bleomycin | Non-Hodgkin lymphoma | | MOPP | Mechlorethamine, Oncovin (vincristine), procarbazine, prednisone | Hodgkin's lymphoma | | PCV | Procarbazine, CCNU (lomustine), vincristine | Brain tumors | | ProMACE-MOPP | Methotrexate, Adriamycin (doxorubicin), cyclophosphamide, etoposide + MOPP | Non-Hodgkin lymphoma | | ProMACE-CytaBOM | Prednisone, doxorubicin (adriamycin), cyclophosphamide, etoposide, cytarabine, bleomycin, Oncovin (vincristine), methotrexate, leucovorin | Non-Hodgkin lymphoma | | R-FCM | Rituximab, fludarabine, cyclophosphamide, mitoxantrone | B cell non-Hodgkin lymphoma | | Stanford V | Doxorubicin, mechlorethamine, bleomycin, vinblastine, vincristine, etoposide, prednisone | Hodgkin's lymphoma | | Thal/Dex | Thalidomide, dexamethasone | Multiple myeloma | | VAC | Vincristine, Actinomycin, Cyclophosphamide | Rhabdomyosarcoma | | VAD | Vincristine, Adriamycin (doxorubicin), dexamethasone | Multiple myeloma | | VAPEC-B | Vincristine, Adriamycin (doxorubicin), prednisone, etoposide, cyclophosphamide, bleomycin | Hodgkin's lymphoma | [edit] See also [edit] References - ^ Mayer, RJ, Targeted therapy for advanced colorectal cancer -- more is not always better, N Engl J Med. 2009;360:623
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