Cefradine

Systematic (IUPAC) name
(6R,7R)-7-{[(2R)-2-amino-2-(1-cyclohexa-1,4- dienyl)acetyl]amino}-3-methyl-8-oxo-5-thia- 1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Identifiers
CAS number	38821-53-3
ATC code	J01DB09
PubChem	38103
ChemSpider	34933
Chemical data
Formula	C16H19N3O4S
Mol. mass	349.406 g/mol
SMILES	eMolecules & PubChem
Pharmacokinetic data
Bioavailability	Well absorbed
Protein binding	<10%
Metabolism	Nil
Half life	0.9 hours
Excretion	Renal, unchanged
Therapeutic considerations
Pregnancy cat.	?
Legal status	℞ Prescription only
Routes	Oral, IM, IV
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Cefradine (INN) (formerly cephradine BAN) is a first generation cephalosporin antibiotic.

[edit] Indications

It has similar spectrum of activity to cefalexin.

[edit] Formulations

Capsules containing 250 mg or 500 mg, Syrup containing 250 mg/5 ml, or vials for injection containing 500 mg or 1 g.

[edit] References

• British National Formulary 45 March 2003

v • d • e Antibacterials: cell envelope antibiotics (J01C-J01D) Internal to membrane/ (inhibit peptidoglycan subunit synthesis and transport) NAM synthesis inhibition (Fosfomycin) · DADAL/AR inhibitors (Cycloserine) · bactoprenol inhibitors (Bacitracin) Glycopeptide/ (inhibit PG chain elongation) Vancomycin# (Oritavancin, Telavancin) · Teicoplanin (Dalbavancin) · Ramoplanin β-lactams/ (inhibit cross-links with PBP) Penicillins/ (penams) Extended sp. aminopenicillins: Amoxicillin#  · Ampicillin# (Pivampicillin, Hetacillin, Bacampicillin, Metampicillin, Talampicillin) · Epicillin carboxypenicillins: Carbenicillin (Carindacillin) · Ticarcillin · Temocillin ureidopenicillins: Azlocillin · Piperacillin · Mezlocillin other: Mecillinam (Pivmecillinam) · Sulbenicillin Narrow sp. β-lactamase sensitive Benzylpenicillin (G)#: Clometocillin · Benzathine benzylpenicillin#  · Procaine benzylpenicillin# · Azidocillin · Penamecillin Phenoxymethylpenicillin (V)#: Propicillin · Benzathine phenoxymethylpenicillin · Pheneticillin β-lactamase resistant Cloxacillin# (Dicloxacillin, Flucloxacillin) · Oxacillin · Meticillin · Nafcillin Penems Faropenem Carbapenems Biapenem · Doripenem · Ertapenem · Imipenem · Meropenem · Panipenem Cephalosporins/ (cephems) 1st (PEcK) Cefazolin# · Cefacetrile · Cefadroxil · Cefalexin · Cefaloglycin · Cefalonium · Cefaloridine · Cefalotin · Cefapirin · Cefatrizine · Cefazedone · Cefazaflur · Cefradine · Cefroxadine · Ceftezole 2nd (HEN) Cefaclor · Cefamandole · Cefminox · Cefonicid · Ceforanide · Cefotiam · Cefprozil · Cefbuperazone · Cefuroxime · Cefuzonam · cephamycin (Cefoxitin, Cefotetan, Cefmetazole) · carbacephem (Loracarbef) 3rd Cefixime# · Ceftazidime# · Ceftriaxone# · Cefcapene · Cefdaloxime · Cefdinir · Cefditoren · Cefetamet · Cefmenoxime · Cefodizime · Cefoperazone · Cefotaxime · Cefpimizole · Cefpiramide · Cefpodoxime · Cefsulodin · Cefteram · Ceftibuten · Ceftiolene · Ceftizoxime · oxacephem (Flomoxef, Latamoxef ‡) 4th Cefepime · Cefozopran · Cefpirome · Cefquinome 5th Ceftobiprole Veterinary Ceftiofur · Cefquinome · Cefovecin Monobactams Aztreonam · Tigemonam β-lactamase inhibitors penam (Sulbactam, Tazobactam) · clavam (Clavulanic acid) Combinations Co-amoxiclav (Amoxicillin/clavulanic acid)# · Imipenem/cilastatin# · Ampicillin/sulbactam (Sultamicillin) · Piperacillin/tazobactam Other polymyxins/detergent (Colistin, Polymyxin B) · depolarizing (Daptomycin) · hydrolyze NAM-NAG (Lysozyme) #WHO-EM. ‡Withdrawn from market. CLINICAL TRIALS: †Phase III. §Never to phase III

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