Cecilio may refer to: - Cecilio Apostol (1877–1938), a Filipino poet
- Cecilio Báez (1862–1941), provisional President of Paraguay 1905–1906
- Cecilio Guante (born 1960), a former professional Major League Baseball player
- Cecilio Lopes (born 1979), a Cape Verdean international football player
- Cecilio Putong, a Filipino educator, writer, Boy Scout leader, UNESCO fellow, author, pensionado and Philippine Secretary of Education
- Cecilio Romaña (1899–1997), an Argentinian physician remembered for describing Romaña's sign
- José Cecilio del Valle (1780–1834), first president of United Provinces of Central America
- Ronaldo Cecilio Leiva, a Guatemalan military officer, Minister of Defence 2006–2008
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