Cation channels of sperm Information & Cation channels of sperm Links at HealthHaven.com

cation channel, sperm associated 3
Identifiers
Symbol	CATSPER3
IUPHAR	CatSper3
Entrez	347732
HUGO	20819
OMIM	609120
RefSeq	NM_178019
UniProt	Q86XQ3
Other data
Locus	Chr. 5 q31.2

cation channel, sperm associated 2
Identifiers
Symbol	CATSPER3
IUPHAR	CatSper3
Entrez	117155
HUGO	18810
OMIM	607249
RefSeq	NM_172097
UniProt	Q96P55
Other data
Locus	Chr. 15 q13-q15

cation channel, sperm associated 1
Identifiers
Symbol	CATSPER1
IUPHAR	CatSper1
Entrez	117144
HUGO	17116
OMIM	606389
RefSeq	NM_053054
UniProt	Q8NEC5
Other data
Locus	Chr. 11 q12.1

cation channel, sperm associated 4
Identifiers
Symbol	CATSPER4
IUPHAR	CatSper4
Entrez	378807
HUGO	23220
OMIM	609121
RefSeq	XM_371237
UniProt	Q7RTX7
Other data
Locus	Chr. 1 p35.3

The cation channels of sperm also known as Catsper channels or CatSper, are ion channels that are related to the two-pore channels and distantly related to TRP channels. The four members of this family form voltage-gated Ca²⁺ channels that seem to be specific to sperm. These channels are required for proper fertilization.^[1] The study of these channels has been slow because they do not traffic to the cell membrane in many heterologous systems.

[edit] See also

Acrosome reaction

[edit] References

^ Qi H, Moran MM, Navarro B, Chong JA, Krapivinsky G, Krapivinsky L, Kirichok Y, Ramsey IS, Quill TA, Clapham DE (January 2007). "All four CatSper ion channel proteins are required for male fertility and sperm cell hyperactivated motility". Proc. Natl. Acad. Sci. U.S.A. 104 (4): 1219–23. doi:10.1073/pnas.0610286104. PMID 17227845.

[edit] External links

MeSH CATSPER1+protein,+human
"CatSper and Two-Pore Channels". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/IC/FamilyMenuForward?familyId=13.

[pmid17227845-0] Qi H, Moran MM, Navarro B, Chong JA, Krapivinsky G, Krapivinsky L, Kirichok Y, Ramsey IS, Quill TA, Clapham DE (January 2007). "All four CatSper ion channel proteins are required for male fertility and sperm cell hyperactivated motility". Proc. Natl. Acad. Sci. U.S.A. 104 (4): 1219–23. doi:10.1073/pnas.0610286104. PMID 17227845.

[1]