Cafestol
Systematic (IUPAC) name
(3bS,5aS,7R,8R,10aS,10bS)-3b,4,5,6,7,8,9,10,10a,10b,11,12-Dodecahydro- 7-hydroxy-10b-methyl-5a,8-methano-5aH-cyclohepta[5,6]naphtho[2,1-b]furan-7-methanol
Identifiers
CAS number	469-83-0
ATC code	none
PubChem	108052
Chemical data
Formula	C20H28O3
Mol. mass	316.439 g/mol
Physical data
Melt. point	158–162 °C (316–324 °F)
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status	Legal everywhere
Routes	Oral

Cafestol is a diterpene molecule present in coffee.

A typical bean of Coffea arabica contains about 0.6% cafestol by weight. Cafestol is present in highest quantity in unfiltered coffee drinks such as French press coffee or Greek coffee. In filtered coffee drinks such as drip brewed coffee, it is present in only negligible amounts.

Studies have shown that regular consumption of boiled coffee increases serum cholesterol by 8% in men and 10% in women. For those drinking filter coffee, the effect was only significant for women.^{[citation needed]}

Cafestol has also shown anticarcinogenic properties in rats. ^[1]

According to a 2007 study from Dr. David Moore's lab at Baylor College of Medicine^[2], cafestol may act as an agonist ligand for the nuclear receptor Farnesoid X receptor and Pregnane X receptor, blocking cholesterol homeostasis.

[edit] See also

• Kahweol

[edit] References

[edit] External links

• NIH review of toxicology of cafestol and kahweol
• The cholesterol-raising factor from coffee beans, cafestol, as an agonist ligand for the farnesoid and pregnane X receptors

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