The Caño Manamo is a distributary of the Orinoco River. It branches northwards from the main channel of the Orinoco to delimit the western edge of the Orinoco Delta, ultimately emptying into the Gulf of Paria. Tucupita, the capital of Delta Amacuro state, is located on the east bank (right) of the Caño Manamo. Manamo is a warao word meaning two.

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Coordinates: 9°55′N 62°16′W / 9.917°N 62.267°W / 9.917; -62.267